Synthesis of PIPs at the Golgi membrane

Stable Identifier
R-HSA-1660514
Type
Pathway
Species
Homo sapiens
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Summation

At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) is primarily generated from phosphorylation of phosphatidylinositol (PI). Other phosphoinositides are also generated by the action of various kinases and phosphatases such as: phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Godi et al. 1999, Minogue et al. 2001, Rohde et al. 2003, Sbrissa et al. 2007, Sbrissa et al. 2008, Domin et al. 2000, Arcaro et al. 2000).

Literature References
PubMed ID Title Journal Year
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J

Mol Cell Biol 2000
11279162 Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family

Minogue, S, Anderson, JS, Waugh, MG, dos Santos, M, Corless, S, Cramer, R, Hsuan, JJ

J Biol Chem 2001
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Domin, J, Gaidarov, I, Smith, ME, Keen, JH, Waterfield, MD

J Biol Chem 2000
17556371 Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex

Sbrissa, D, Ikonomov, OC, Fu, Z, Ijuin, T, Gruenberg, J, Takenawa, T, Shisheva, A

J Biol Chem 2007
10559940 ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

Godi, A, Pertile, P, Meyers, R, Marra, P, Di Tullio, G, Iurisci, C, Luini, A, Corda, D, De Matteis, MA

Nat Cell Biol 1999
18950639 ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality

Sbrissa, D, Ikonomov, OC, Fenner, H, Shisheva, A

J Mol Biol 2008
14527956 The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex

Rohde, HM, Cheong, FY, Konrad, G, Paiha, K, Mayinger, P, Boehmelt, G

J Biol Chem 2003
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