Synthesis of PIPs at the late endosome membrane

Stable Identifier
R-HSA-1660517
Type
Pathway
Species
Homo sapiens
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Summation

At the late endosome membrane, the primary event is the dephosphorylation of the phosphoinositide phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 2007, Sbrissa et al. 2008, Cao et al. 2007, Cao et al. 2008, Arcaro et al. 2000, Kim et al. 2002).

Literature References
PubMed ID Title Journal Year
18524850 Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking

Cao, C, Backer, JM, Laporte, J, Bedrick, EJ, Wandinger-Ness, A

Mol Biol Cell 2008
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J

Mol Cell Biol 2000
17556371 Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex

Sbrissa, D, Ikonomov, OC, Fu, Z, Ijuin, T, Gruenberg, J, Takenawa, T, Shisheva, A

J Biol Chem 2007
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP

Traffic 2007
11733541 Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease

Kim, SA, Taylor, GS, Torgersen, KM, Dixon, JE

J Biol Chem 2002
18950639 ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality

Sbrissa, D, Ikonomov, OC, Fenner, H, Shisheva, A

J Mol Biol 2008
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