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MYD88 [cytosol]
Stable Identifier
R-HSA-166059
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MyD88
Icon
Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
DHX36 or DHX9 binds MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with the activated TLR receptor (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with the activated TLR receptor (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MYD88 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99836 MYD88
Gene Names
MYD88
Chain
chain:1-296
Reference Genes
BioGPS Gene:4615 MYD88
COSMIC (genes):MYD88 MYD88
CTD Gene:4615 MYD88
dbSNP Gene:4615 MYD88
ENSEMBL:ENSG00000172936 MYD88
ENSEMBL_homo_sapiens_GENE:ENSG00000172936.18 MYD88
HGNC:7562 MYD88
KEGG Gene (Homo sapiens):4615 MYD88
Monarch:4615 MYD88
NCBI Gene:4615 MYD88
OMIM:602170 MYD88
UCSC:Q99836 MYD88
Reference Transcript
RefSeq:NM_002468.4 MYD88
RefSeq:NM_001172568.1 MYD88
RefSeq:NM_001172569.1 MYD88
RefSeq:NM_001172566.1 MYD88
Other Identifiers
11720623_a_at
11720624_a_at
11747538_a_at
11747539_x_at
16939127
209124_PM_at
209124_at
2617564
2617565
2617566
2617567
2617570
2617572
2617574
2617576
2617577
2617578
38369_at
4615
8078729
A_14_P101666
A_14_P118253
A_23_P362659
A_23_P92140
GE59370
GO:0002238
GO:0002269
GO:0002283
GO:0002376
GO:0002755
GO:0003824
GO:0005102
GO:0005121
GO:0005123
GO:0005149
GO:0005515
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006909
GO:0006915
GO:0006954
GO:0007165
GO:0007166
GO:0007254
GO:0008063
GO:0009615
GO:0009682
GO:0009986
GO:0010008
GO:0010243
GO:0010467
GO:0010468
GO:0010628
GO:0012501
GO:0014004
GO:0014070
GO:0014075
GO:0016064
GO:0016071
GO:0016192
GO:0019221
GO:0019897
GO:0022008
GO:0023052
GO:0030154
GO:0031234
GO:0031410
GO:0031663
GO:0032481
GO:0032494
GO:0032496
GO:0032675
GO:0032680
GO:0032722
GO:0032731
GO:0032740
GO:0032747
GO:0032755
GO:0032757
GO:0032760
GO:0032991
GO:0034142
GO:0034158
GO:0035325
GO:0035591
GO:0038172
GO:0042127
GO:0042742
GO:0042802
GO:0042832
GO:0043123
GO:0043200
GO:0043226
GO:0043588
GO:0043621
GO:0045087
GO:0045471
GO:0045944
GO:0046330
GO:0048661
GO:0048856
GO:0048870
GO:0050671
GO:0050727
GO:0050830
GO:0051092
GO:0051607
GO:0060090
GO:0060337
GO:0060907
GO:0065003
GO:0070498
GO:0070555
GO:0070935
GO:0070944
GO:0070976
GO:0071222
GO:0071260
GO:0071310
GO:0090557
GO:0098542
GO:0140052
GO:0140096
GO:0140097
GO:0140104
GO:0140657
GO:0140674
GO:1900017
GO:1900227
GO:1902622
GO:2000338
GO:2000341
HMNXSV003055007
ILMN_1738523
PH_hs_0004695
TC03000187.hg
U70451_at
g1763090_3p_at
Participates
as a component of
DHX36:CpG:MyD88 [cytosol] (Homo sapiens)
DHX9:CpG:MyD88 [cytosol] (Homo sapiens)
MYD88 dimer [cytosol] (Homo sapiens)
as an input of
DHX36 or DHX9 binds MyD88 (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 forms a complex with the activated TLR receptor (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
Other forms of this molecule
MyD88 R196C [cytosol]
MyD88 E52del [cytosol]
MyD88 L93P [cytosol]
MyD88 S34Y [cytosol]
MyD88 E65del [cytosol]
MYD88 [endosome membrane]
MYD88 [plasma membrane]
Inferred To
Myd88 [cytosol]
(Drosophila melanogaster)
Myd88 [cytosol]
(Mus musculus)
Myd88 [cytosol]
(Rattus norvegicus)
MYD88 [cytosol]
(Bos taurus)
MYD88 [cytosol]
(Canis familiaris)
MYD88 [cytosol]
(Gallus gallus)
MYD88 [cytosol]
(Sus scrofa)
myd88 [cytosol]
(Danio rerio)
myd88 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001166037.1
,
NP_002459.2
,
NP_001166039.1
,
NP_001166040.1
OpenTargets
ENSG00000172936
HPA
ENSG00000172936-MYD88
GeneCards
Q99836
Ensembl
ENST00000421516
,
ENST00000651800
,
ENSP00000497991
,
ENSP00000499012
,
ENSP00000401399
,
ENSP00000391753
,
ENSP00000498360
,
ENST00000650112
,
ENST00000417037
,
ENST00000650905
,
ENSG00000172936
PRO
Q99836
Pharos - Targets
Q99836
Orphanet
18435
PDB
4DOM
,
2JS7
,
7BER
,
7L6W
,
3MOP
,
7BEQ
,
2Z5V
,
4EO7
,
6I3N
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.958
40
UniProt:Q9NWZ3 IRAK4
9
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [cytosol]
(R-HSA-166081)
0.922
15
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.861
9
UniProt:O43791 SPOP
1
SPOP [nucleoplasm]
(R-HSA-5635035)
0.837
8
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.758
4
UniProt:O60603 TLR2
3
TLR2 [plasma membrane]
(R-HSA-9637646)
TLR2 [secretory granule membrane]
(R-HSA-6804777)
TLR2 [plasma membrane]
(R-HSA-167992)
0.737
4
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.723
4
UniProt:O14836 TNFRSF13B
1
TAC1 [plasma membrane]
(R-HSA-5668752)
0.692
12
UniProt:Q6SZW1 SARM1
0.622
5
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.602
4
UniProt:Q8NF50 DOCK8
1
DOCK8 [cytosol]
(R-HSA-1011619)
0.576
3
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.573
3
UniProt:P13682 ZNF35
0.556
3
UniProt:Q69FE3 Q69FE3
0.556
5
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:Q6IQ16 SPOPL
1
SPOPL [nucleoplasm]
(R-HSA-5635036)
0.556
3
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.543
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.543
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.543
3
UniProt:Q9UGK3 STAP2
2
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
STAP2 [cytosol]
(R-HSA-8848028)
0.524
3
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.524
6
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.462
8
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