Sphingolipid de novo biosynthesis

Stable Identifier
R-HSA-1660661
Type
Pathway
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Glycosphingolipid biosynthesis is based on salvage of sphingolipids and de novo sphingolipid synthesis. Sphingoid-1-phosphate signalling molecules are synthesized through the same pathway, which starts with the transfer of a fatty acid onto serine. The diversity of products results from later dehydrogenation or hydroxylation of fatty acid moieties, as well as the usage of fatty acids of different lengths. Biosynthesis takes place in the endoplasmic reticulum lumen and the cytosol. Lipophilic products are transported to other membranes via a specialized transporter (CERT1) or the secretory pathway. Soluble sphingoid-1-phosphates are exported by multiple transporters in the plasma membrane (reviewed by Merrill 2002, Gault et al. 2010).
Literature References
PubMed ID Title Journal Year
20919643 An overview of sphingolipid metabolism: from synthesis to breakdown

Gault, CR, Hannun, YA, Obeid, LM

Adv Exp Med Biol 2010
12011104 De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

Merrill AH, Jr

J Biol Chem 2002
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