IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].
Lin, SC, Lo, YC, Wu, H
Suzuki, N, Suzuki, S, Yeh, WC
Towb, P, Sun, H, Wasserman, SA
Motshwene, PG, Moncrieffe, MC, Grossmann, JG, Kao, C, Ayaluru, M, Sandercock, AM, Robinson, CV, Latz, E, Gay, NJ
Moncrieffe, MC, Grossmann, JG, Gay, NJ
Li, S, Strelow, A, Fontana, EJ, Wesche, H
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