Reactome | IRAK3 [cytosol]

IRAK3 [cytosol]

Stable Identifier

R-HSA-166103

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IRAK-M

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y616 IRAK3

Gene Names

IRAK3

Chain

chain:1-596

Reference Genes

BioGPS Gene:11213 IRAK3

COSMIC (genes):IRAK3 IRAK3

CTD Gene:11213 IRAK3

dbSNP Gene:11213 IRAK3

ENSEMBL:ENSG00000090376 IRAK3

ENSEMBL_homo_sapiens_GENE:ENSG00000090376.11 IRAK3

HGNC:17020 IRAK3

KEGG Gene (Homo sapiens):11213 IRAK3

Monarch:11213 IRAK3

NCBI Gene:11213 IRAK3

OMIM:604459 IRAK3

UCSC:Q9Y616 IRAK3

Reference Transcript

Other Identifiers

11213

11726894_a_at

11726895_a_at

11726896_a_at

11742017_a_at

16753670

213817_PM_at

213817_at

220034_PM_at

220034_at

3420443

3420444

3420449

3420451

3420453

3420455

3420456

3420459

3420461

3420462

3420477

3420478

3420479

3420480

3420481

3420482

3420483

3420484

3420485

3420486

3420488

3420490

3420492

3420493

3420494

38510_at

58254_at

7956878

A_14_P124441

A_23_P162300

A_32_P83256

GE56178

GE80872

GO:0000166

GO:0000287

GO:0001819

GO:0001960

GO:0002376

GO:0002755

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0007165

GO:0008063

GO:0009615

GO:0010933

GO:0010936

GO:0016740

GO:0019221

GO:0019901

GO:0023052

GO:0030163

GO:0032088

GO:0032494

GO:0032496

GO:0032695

GO:0032715

GO:0032720

GO:0034122

GO:0035556

GO:0036211

GO:0042177

GO:0042803

GO:0043226

GO:0043242

GO:0043244

GO:0043330

GO:0043407

GO:0045824

GO:0046982

GO:0048856

GO:0051092

GO:0070498

GO:0070555

GO:0071222

GO:0071345

GO:0098542

GO:0140096

HMNXSV003014571

HMNXSV003018673

Hs.170056.0.S1_3p_at

ILMN_1661695

ILMN_1913678

PH_hs_0013736

PH_hs_0014243

TC12000591.hg

TC12002425.hg

g6005791_3p_at

This entity regulates

Negatively

Inferred To

IRAK3 [cytosol] (Bos taurus)

IRAK3 [cytosol] (Canis familiaris)

IRAK3 [cytosol] (Mus musculus)

IRAK3 [cytosol] (Sus scrofa)

Irak3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_009130.2, NP_001135995.1

ZINC - World Drugs

IRAK3_HUMAN

Guide to Pharmacology - Targets

2044

OpenTargets

ENSG00000090376

ZINC - FDA approved

IRAK3_HUMAN

ZINC - Substances

IRAK3_HUMAN

ZINC - Biogenic

IRAK3_HUMAN

ZINC target

Q9Y616

PRO

Q9Y616

PDB

5UKE, 6ZIW, 6RUU

ZINC - Investigational

IRAK3_HUMAN

GeneCards

Q9Y616

HPA

ENSG00000090376-IRAK3

Ensembl

ENSG00000090376, ENST00000261233, ENSP00000409852, ENSP00000261233, ENST00000457197

Pharos - Targets

Q9Y616

ZINC - Predictions - Purchasable

IRAK3_HUMAN

HMDB Protein

HMDBP08734

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.675	4
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.564	3
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.564	3