First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal

Stable Identifier
R-HSA-166119
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
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First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.

Literature References
PubMed ID Title Journal Year
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Li, S, Strelow, A, Fontana, EJ, Wesche, H

Proc Natl Acad Sci U S A 2002
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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