Reactome | TIRAP [cytosol]

TIRAP [cytosol]

Stable Identifier

R-HSA-166141

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mal Splice Alternative 1

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Locations in the PathwayBrowser for interactor UniProt:O00206 TLR4

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External Reference Information

External Reference

UniProt:P58753 TIRAP

Gene Names

TIRAP, MAL

Chain

chain:1-221

Reference Genes

BioGPS Gene:114609 TIRAP

COSMIC (genes):TIRAP TIRAP

CTD Gene:114609 TIRAP

dbSNP Gene:114609 TIRAP

ENSEMBL:ENSG00000150455 TIRAP

ENSEMBL_homo_sapiens_GENE:ENSG00000150455.15 TIRAP

HGNC:17192 TIRAP

KEGG Gene (Homo sapiens):114609 TIRAP

Monarch:114609 TIRAP

NCBI Gene:114609 TIRAP

OMIM:606252 TIRAP

UCSC:P58753 TIRAP

Reference Transcript

Other Identifiers

114609

11737288_a_at

11737408_a_at

11760053_at

11760054_x_at

1552360_PM_a_at

1552360_a_at

1552804_PM_a_at

1552804_a_at

1554091_PM_a_at

1554091_a_at

1557908_PM_at

1557908_at

16733262

239796_PM_x_at

239796_x_at

3355090

3355092

3355095

3355097

3355098

3355099

3355100

3355101

3355102

3355103

3355104

3355105

3355106

3355107

3355108

3355109

3355110

3355111

48297_at

62622_at

62656_r_at

7945086

A_23_P202905

A_23_P397856

A_33_P3252719

GE56920

GE87880

GO:0002376

GO:0002755

GO:0005080

GO:0005515

GO:0005546

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006954

GO:0007165

GO:0007166

GO:0007249

GO:0008289

GO:0009986

GO:0016020

GO:0016071

GO:0023052

GO:0030099

GO:0030139

GO:0030154

GO:0030674

GO:0030890

GO:0031234

GO:0031334

GO:0031410

GO:0032496

GO:0032587

GO:0032648

GO:0032735

GO:0032738

GO:0032755

GO:0032757

GO:0032760

GO:0032872

GO:0034137

GO:0034141

GO:0034142

GO:0034145

GO:0035591

GO:0035662

GO:0035663

GO:0035665

GO:0042802

GO:0043123

GO:0043226

GO:0045087

GO:0045088

GO:0046330

GO:0048856

GO:0048870

GO:0050830

GO:0051092

GO:0060090

GO:0065003

GO:0070374

GO:0070935

GO:0071221

GO:0071223

GO:0090023

GO:0098542

GO:2000340

GO:2000343

HMNXSV003029271

HMNXSV003056919

Hs.180680.0.A1_3p_at

Hs2.17681.1.S1_3p_a_at

Hs2.17681.2.S1_3p_a_at

Hs2.17681.2.S1_3p_at

Hs2.17681.3.S1_3p_s_at

Hs2.17681.4.S1_3p_at

Hs2.17681.4.S1_3p_x_at

ILMN_1776703

ILMN_1812432

ILMN_2290679

ILMN_2400603

PH_hs_0001594

PH_hs_0031034

TC11001172.hg

Participates

as an input of

TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)

as a component of

TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-4Y-TIRAP [plasma membrane]

Inferred To

TIRAP [cytosol] (Bos taurus)

TIRAP [cytosol] (Canis familiaris)

TIRAP [cytosol] (Gallus gallus)

TIRAP [cytosol] (Sus scrofa)

tirap [cytosol] (Xenopus tropicalis)

Tirap [cytosol] (Mus musculus)

Tirap [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_683708.1, NP_001305706.1, XP_016872651.1, XP_005271456.2, XP_011540878.1, NP_001034750.1, NP_001305705.1

OpenTargets

ENSG00000150455

GeneCards

P58753

HPA

ENSG00000150455-TIRAP

Ensembl

ENST00000392680, ENSP00000376445, ENST00000700492, ENST00000392678, ENST00000700488, ENSP00000376447, ENSP00000376446, ENST00000392679, ENSG00000150455, ENSP00000515021, ENSP00000515016, ENSP00000515017, ENSP00000436967, ENST00000700489, ENSP00000515018, ENST00000700490, ENST00000700491, ENST00000479770, ENSP00000515019

PRO

P58753

Pharos - Targets

P58753

PDB

2Y92, 3UB3, 5UZB, 2NDH, 3UB2, 3UB4, 4LQD, 4FZ5, 5T7Q

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.861	9
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.807	6
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.623	3
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.592	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.564	2
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.558	9
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.499	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.499	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.499	2
UniProt:Q9NWZ3 IRAK4	9	IRAK4 Q293* [cytosol] (R-HSA-5602426) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 E402* [cytosol] (R-HSA-5602517) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [cytosol] (R-HSA-166081)	0.499	2
UniProt:Q96A33 CCD47			0.499	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.463	3
UniProt:P0C6I1-PRO_0000324727 C			0.463	2
UniProt:P22366	1	Myd88 [cytosol] (R-MMU-166059)	0.462	3

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