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TIRAP [cytosol]
Stable Identifier
R-HSA-166141
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Mal Splice Alternative 1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
TIRAP [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
TIRAP [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
TIRAP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P58753 TIRAP
Gene Names
TIRAP, MAL
Chain
chain:1-221
Reference Genes
BioGPS Gene:114609 TIRAP
COSMIC (genes):TIRAP TIRAP
CTD Gene:114609 TIRAP
dbSNP Gene:114609 TIRAP
ENSEMBL:ENSG00000150455 TIRAP
ENSEMBL_homo_sapiens_GENE:ENSG00000150455.15 TIRAP
HGNC:17192 TIRAP
KEGG Gene (Homo sapiens):114609 TIRAP
Monarch:114609 TIRAP
NCBI Gene:114609 TIRAP
OMIM:606252 TIRAP
UCSC:P58753 TIRAP
Reference Transcript
RefSeq:XM_017017162.1 TIRAP
RefSeq:NM_001318776.1 TIRAP
RefSeq:NM_001039661.1 TIRAP
RefSeq:NM_148910.2 TIRAP
RefSeq:XM_011542576.2 TIRAP
RefSeq:NM_001318777.1 TIRAP
RefSeq:XM_005271399.3 TIRAP
Other Identifiers
114609
11737288_a_at
11737408_a_at
11760053_at
11760054_x_at
1552360_PM_a_at
1552360_a_at
1552804_PM_a_at
1552804_a_at
1554091_PM_a_at
1554091_a_at
1557908_PM_at
1557908_at
16733262
239796_PM_x_at
239796_x_at
3355090
3355092
3355095
3355097
3355098
3355099
3355100
3355101
3355102
3355103
3355104
3355105
3355106
3355107
3355108
3355109
3355110
3355111
48297_at
62622_at
62656_r_at
7945086
A_23_P202905
A_23_P397856
A_33_P3252719
GE56920
GE87880
GO:0002376
GO:0002755
GO:0005080
GO:0005515
GO:0005546
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006954
GO:0007165
GO:0007166
GO:0007249
GO:0008289
GO:0009986
GO:0016020
GO:0016071
GO:0023052
GO:0030099
GO:0030139
GO:0030154
GO:0030674
GO:0030890
GO:0031234
GO:0031334
GO:0031410
GO:0032496
GO:0032587
GO:0032648
GO:0032735
GO:0032738
GO:0032755
GO:0032757
GO:0032760
GO:0032872
GO:0034137
GO:0034141
GO:0034142
GO:0034145
GO:0035591
GO:0035662
GO:0035663
GO:0035665
GO:0042802
GO:0043123
GO:0043226
GO:0045087
GO:0045088
GO:0046330
GO:0048856
GO:0048870
GO:0050830
GO:0051092
GO:0060090
GO:0065003
GO:0070374
GO:0070935
GO:0071221
GO:0071223
GO:0090023
GO:0098542
GO:2000340
GO:2000343
HMNXSV003029271
HMNXSV003056919
Hs.180680.0.A1_3p_at
Hs2.17681.1.S1_3p_a_at
Hs2.17681.2.S1_3p_a_at
Hs2.17681.2.S1_3p_at
Hs2.17681.3.S1_3p_s_at
Hs2.17681.4.S1_3p_at
Hs2.17681.4.S1_3p_x_at
ILMN_1776703
ILMN_1812432
ILMN_2290679
ILMN_2400603
PH_hs_0001594
PH_hs_0031034
TC11001172.hg
Participates
as an input of
TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)
as a component of
TIRAP:PI(4,5)P2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-4Y-TIRAP [plasma membrane]
Inferred To
TIRAP [cytosol]
(Bos taurus)
TIRAP [cytosol]
(Canis familiaris)
TIRAP [cytosol]
(Gallus gallus)
TIRAP [cytosol]
(Sus scrofa)
tirap [cytosol]
(Xenopus tropicalis)
Tirap [cytosol]
(Mus musculus)
Tirap [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_683708.1
,
NP_001305706.1
,
XP_016872651.1
,
XP_005271456.2
,
XP_011540878.1
,
NP_001034750.1
,
NP_001305705.1
OpenTargets
ENSG00000150455
GeneCards
P58753
HPA
ENSG00000150455-TIRAP
Ensembl
ENST00000392680
,
ENSP00000376445
,
ENST00000700492
,
ENST00000392678
,
ENST00000700488
,
ENSP00000376447
,
ENSP00000376446
,
ENST00000392679
,
ENSG00000150455
,
ENSP00000515021
,
ENSP00000515016
,
ENSP00000515017
,
ENSP00000436967
,
ENST00000700489
,
ENSP00000515018
,
ENST00000700490
,
ENST00000700491
,
ENST00000479770
,
ENSP00000515019
PRO
P58753
Pharos - Targets
P58753
PDB
2Y92
,
3UB3
,
5UZB
,
2NDH
,
3UB2
,
3UB4
,
4LQD
,
4FZ5
,
5T7Q
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.861
9
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.807
6
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.623
3
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.592
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
2
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.558
9
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.499
2
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.499
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.499
2
UniProt:Q9NWZ3 IRAK4
9
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [cytosol]
(R-HSA-166081)
0.499
2
UniProt:Q96A33 CCD47
0.499
2
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.463
3
UniProt:P0C6I1-PRO_0000324727 C
0.463
2
UniProt:P22366
1
Myd88 [cytosol]
(R-MMU-166059)
0.462
3
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