TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)

Stable Identifier
R-HSA-166175
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane, cytosol
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TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
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TRIF (TICAM1) mediates the MyD88-independent pathway from TLR4.

Literature References
PubMed ID Title Journal Year
14517278 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters

Fitzgerald, KA, Rowe, DC, Barnes, BJ, Caffrey, DR, Visintin, A, Latz, E, Monks, BG, Pitha-Rowe, PM, Golenbock, DT

J Exp Med 2003
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Yamamoto, M, Sato, S, Hemmi, H, Hoshino, K, Kaisho, T, Sanjo, H, Takeuchi, O, Sugiyama, M, Okabe, M, Takeda, K

Science 2003
14556004 TRAM is specifically involved in the Toll-like receptor 4-mediated

Yamamoto, M, Sato, S, Hemmi, H, Uematsu, S, Hoshino, K, Kaisho, T, Takeuchi, O, Takeda, K

Nat Immunol 2003
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gay, NJ  (2006-04-24)
Gillespie, ME  (2010-11-30)
Fitzgerald, KA  (2012-11-13)
Created
de Bono, B  (2005-08-19)