TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)

Stable Identifier
R-HSA-166175
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
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TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
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TRIF (TICAM1) mediates the MyD88-independent pathway from TLR4.

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H

Science 2003
14517278 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters

Fitzgerald, KA, Rowe, DC, Latz, E, Barnes, BJ, Golenbock, DT, Pitha-Rowe, PM, Monks, BG, Caffrey, DR, Visintin, A

J Exp Med 2003
14556004 TRAM is specifically involved in the Toll-like receptor 4-mediated

Takeuchi, O, Hoshino, K, Takeda, K, Sato, S, Yamamoto, M, Kaisho, T, Uematsu, S, Hemmi, H

Nat Immunol 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Canis familiaris)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gillespie, ME  (2010-11-30)
Fitzgerald, KA  (2012-11-13)
Gay, NJ  (2006-04-24)
Created
de Bono, B  (2005-08-19)
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