Reactome | p-4S,T404-IRF3 [cytosol]

p-4S,T404-IRF3 [cytosol]

Stable Identifier

R-HSA-166258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T,4S-IRF3

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
        
        phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Homo sapiens)
        
        p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Homo sapiens)
        
        p-4S,T404-IRF3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14653 IRF3

Gene Names

IRF3

Chain

chain:1-427

Reference Genes

BioGPS Gene:3661 IRF3

COSMIC (genes):IRF3 IRF3

CTD Gene:3661 IRF3

dbSNP Gene:3661 IRF3

ENSEMBL:ENSG00000126456 IRF3

ENSEMBL:ENSG00000126456.16 IRF3

HGNC:6118 IRF3

KEGG Gene (Homo sapiens):3661 IRF3

Monarch:3661 IRF3

NCBI Gene:3661 IRF3

OMIM:603734 IRF3

UCSC:Q14653 IRF3

Reference Transcript

Other Identifiers

11718672_x_at

11745498_a_at

11745499_x_at

11753805_a_at

11753806_x_at

11756572_x_at

16874347

202621_PM_at

202621_at

3661

371_at

3867989

3867990

3867991

3867993

3867995

3867996

3867997

3867998

3867999

3868000

3868001

3868002

3868003

3868007

3868008

3868009

3868010

3868011

3868012

8038416

A_33_P3327333

GE60425

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001216

GO:0001227

GO:0001228

GO:0001819

GO:0002376

GO:0002753

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006915

GO:0006954

GO:0006974

GO:0009299

GO:0009617

GO:0010468

GO:0012501

GO:0016071

GO:0019904

GO:0023052

GO:0031663

GO:0032481

GO:0032496

GO:0032727

GO:0032728

GO:0035666

GO:0039530

GO:0042802

GO:0042803

GO:0042981

GO:0043123

GO:0043226

GO:0043330

GO:0043565

GO:0045087

GO:0045893

GO:0045944

GO:0050727

GO:0051607

GO:0060337

GO:0060340

GO:0071222

GO:0071360

GO:0071888

GO:0097300

GO:0098542

GO:0098586

GO:0098772

GO:0140110

GO:0140374

GO:0140537

GO:0140677

GO:1990837

GO:1990841

HMNXSV003034896

ILMN_1765649

PH_hs_0004298

TC19001722.hg

Z56281_at

g4504724_3p_at

g4504724_3p_x_at

Participates

as an output of

as an input of

p-T,4S-IRF3 is dimerized (Homo sapiens)

as a member of

p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

p-5S,T404-IRF3 [nucleoplasm]

p-4S,T404-IRF3 [nucleoplasm]

IRF3(272-427) [cytosol]

IRF3(2-271) [cytosol]

IRF3 [cytosol]

Inferred To

phospho-p-4S,T404-IRF3 [cytosol] (Danio rerio)

phospho-p-4S,T404-IRF3 [cytosol] (Xenopus tropicalis)

phospho-IRF3 [cytosol] (Bos taurus)

phospho-IRF3 [cytosol] (Sus scrofa)

phospho-Irf3 [cytosol] (Mus musculus)

phospho-Irf3 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 396

Coordinate

396

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 398

Coordinate

398

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 402

Coordinate

402

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 405

Coordinate

405

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 404

Coordinate

404

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_006723260.1, XP_016882255.1, NP_001184055.1, NP_001184057.1, XP_016882256.1, NP_001184051.1, NP_001184053.1, NP_001184054.1, XP_006723261.1, NP_001184056.1, NP_001184052.1, NP_001562.1

OpenTargets

ENSG00000126456

HPA

ENSG00000126456-IRF3

GeneCards

Q14653

Ensembl

ENST00000377139, ENSP00000472700, ENST00000601291, ENSP00000310127, ENST00000442265, ENSP00000366344, ENST00000596765, ENST00000597198, ENSP00000400378, ENST00000599223, ENSG00000126456, ENSP00000470512, ENSP00000471896, ENSP00000471358, ENSP00000469113, ENST00000309877, ENST00000600022

PRO

Q14653

Pharos - Targets

Q14653

Orphanet

24628

PDB

5JEM, 3A77, 1J2F, 1ZOQ, 5JEL, 6SIV, 1QWT, 5JER, 5JEJ, 2PI0, 7JFL, 5JEK, 2O61, 5JEO, 1T2K, 2O6G, 6SJA, 3QU6

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.97	18
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.929	12
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.92	10
UniProt:P0C6X7-PRO_0000037311 REP			0.656	5
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.612	6
UniProt:Q9Y5Q3 MAFB	1	MAFB [nucleoplasm] (R-HSA-3788667)	0.556	4
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.544	2
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.543	3
UniProt:P10914 IRF1	2	IRF1 [nucleoplasm] (R-HSA-983456) IRF1 [cytosol] (R-HSA-1015686)	0.537	5
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.524	3
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [cytosol] (R-HSA-416633) GRIP1 [plasma membrane] (R-HSA-416638)	0.508	2
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.499	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.499	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.499	2

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