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p-T209,T387-IRAK1 [plasma membrane]
Stable Identifier
R-HSA-166279
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-T209,387-IRAK1, IRAK1 phosphorylated at T209, T387
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-T209,T387-IRAK1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
ENSEMBL_homo_sapiens_GENE:ENSG00000184216.15 IRAK1
HGNC:6112 IRAK1
KEGG Gene (Homo sapiens):3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
RefSeq:NM_001569.3 IRAK1
RefSeq:NM_001025243.1 IRAK1
RefSeq:NM_001025242.1 IRAK1
Other Identifiers
1100_at
11734006_a_at
1555784_PM_s_at
1555784_s_at
17115428
201587_PM_s_at
201587_s_at
3654
4027010
4027011
4027012
4027013
4027014
4027015
4027016
4027017
4027018
4027021
4027022
4027023
4027024
4027027
4027028
4027029
4027031
4027033
4027034
4027037
4027038
4027040
4027041
4027043
4027045
4027046
4027048
4027050
4027051
4027052
4027053
8175977
A_23_P73780
A_33_P3286616
GE62370
GO:0000166
GO:0001959
GO:0002224
GO:0002376
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005811
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007165
GO:0007249
GO:0007254
GO:0008063
GO:0009986
GO:0010008
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0031072
GO:0031410
GO:0031663
GO:0032088
GO:0032481
GO:0032496
GO:0032991
GO:0034134
GO:0034142
GO:0034162
GO:0034605
GO:0035556
GO:0036211
GO:0038172
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0045087
GO:0046777
GO:0046982
GO:0048583
GO:0048661
GO:0051092
GO:0060337
GO:0070498
GO:0070555
GO:0071222
GO:0071345
GO:0071456
GO:0098542
GO:0106310
GO:0140096
GO:1904996
HMNXSV003048644
HMNXSV003053546
Hs2.182018.3.S1_3p_s_at
ILMN_2379130
L76191_at
PH_hs_0010754
TC0X001524.hg
g4755143_3p_s_at
Participates
as a component of
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
Other forms of this molecule
K63polyUb-hp-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
p-S,T-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [cytosol]
p-T209-IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
IRAK1 [cytosol]
Modified Residues
Name
O-phospho-L-threonine at 209
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001020413.1
,
NP_001560.2
,
NP_001020414.1
ZINC - World Drugs
IRAK1_HUMAN
Guide to Pharmacology - Targets
2042
OpenTargets
ENSG00000184216
ZINC - FDA approved
IRAK1_HUMAN
ZINC - Substances
IRAK1_HUMAN
ZINC target
P51617
ZINC - Biogenic
IRAK1_HUMAN
PRO
P51617
PDB
6BFN
ZINC - Investigational
IRAK1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000184216-IRAK1
GeneCards
P51617
Ensembl
ENST00000369980
,
ENSP00000377291
,
ENSP00000358991
,
ENSG00000184216
,
ENST00000369974
,
ENST00000393687
,
ENSP00000358997
Pharos - Targets
P51617
Orphanet
22427
ZINC - Predictions - Purchasable
IRAK1_HUMAN
HMDB Protein
HMDBP08733
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.77
4
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.743
4
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.734
4
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.723
4
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.645
10
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.623
3
UniProt:Q8N2H9-2 PELI3
0.589
2
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
3
UniProt:Q9NWZ3 IRAK4
9
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [cytosol]
(R-HSA-166081)
0.547
2
UniProt:Q5D1E7
1
ZC3H12A [nucleoplasm]
(R-MMU-9774235)
0.544
3
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.527
2
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.527
2
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
2
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:Q8VCW4
2
Unc93b1 [endoplasmic reticulum membrane]
(R-MMU-1678930)
Unc93b1 [Golgi membrane]
(R-MMU-1679064)
0.499
2
UniProt:Q15306 IRF4
2
IRF4 [nucleoplasm]
(R-HSA-9907101)
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q92985 IRF7
5
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
IRF7 [endosome membrane]
(R-HSA-450274)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
IRF7 [cytosol]
(R-HSA-450281)
0.499
2
UniProt:Q86WV6 STING1
5
TMEM173 [plasma membrane]
(R-HSA-6804815)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.499
2
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