Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP

Stable Identifier
R-HSA-166284
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
plasma membrane, cytosol
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Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
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Second, Thr387 in the activation loop is phosphorylated, leading to full enzymatic activity.

Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
Physical Entity
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gay, NJ  (2006-04-24)
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
de Bono, B  (2005-08-23)