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Terminal pathway of complement
Stable Identifier
R-HSA-166665
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Terminal pathway of complement (Homo sapiens)
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After cleavage of C5, C5b undergoes conformational changes and exposes a binding site for C6. C5b6 binds C7 resulting in the exposure of membrane binding sites and incorporation into target membranes. The membrane-bound C5b-7 complex can then bind C8. C5b-8 acts as a polymerizing agent for C9. The first C9 bound to C5b-8 undergoes major structural changes enabling formation of an elongated molecule and allows binding of additional C9 molecules and insertion of C9 cylinders into the target membrane. The number of C9 molecules varies from 1-12 in the membrane, although polymers containing up to fifteen C9 molecules are also possible.
Literature References
PubMed ID
Title
Journal
Year
Fundamental Immunology
Paul, W
2003
Participants
Events
C5b binds C6
(Homo sapiens)
C7 binds C5b:C6
(Homo sapiens)
C5b:C6:C7 translocates to the plasma membrane
(Homo sapiens)
C8 binds C5b:C6:C7
(Homo sapiens)
C9 binds C5b:C6:C7:C8
(Homo sapiens)
Participates
as an event of
Complement cascade (Homo sapiens)
Orthologous Events
Terminal pathway of complement (Bos taurus)
Terminal pathway of complement (Canis familiaris)
Terminal pathway of complement (Gallus gallus)
Terminal pathway of complement (Mus musculus)
Terminal pathway of complement (Rattus norvegicus)
Terminal pathway of complement (Sus scrofa)
Authored
de Bono, B (2004-08-04)
Reviewed
D'Eustachio, P (2006-07-04)
Created
de Bono, B (2005-09-14)
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