Reactome | MBL2 [extracellular region]

MBL2 [extracellular region]

Stable Identifier

R-HSA-166674

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MBL monomer

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds MASP2 (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11226 MBL2

Gene Names

MBL2, COLEC1, MBL

Chain

signal peptide:1-20, chain:21-248

Reference Genes

COSMIC (genes):MBL2 MBL2

dbSNP Gene:4153 MBL2

ENSEMBL:ENSG00000165471 MBL2

Participates

as a component of

MBL2 trimer [extracellular region] (Homo sapiens)

Inferred To

Mbl2 [extracellular region] (Mus musculus)

Mbl2 [extracellular region] (Rattus norvegicus)

MBL2 [extracellular region] (Sus scrofa)

MBL [extracellular region] (Bos taurus)

MBL [extracellular region] (Gallus gallus)

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
mannan [ChEBI:28808]	1	alpha-mannan [plasma membrane] (R-ALL-5621136)	0.945	15
UniProt:P17927 CR1	3	CR1 [ficolin-1-rich granule membrane] (R-HSA-6801286) CR1 [secretory granule membrane] (R-HSA-6801315) CR1 [plasma membrane] (R-HSA-977369)	0.623	8
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.558	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.558	5
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.544	6
UniProt:O75648 TRMU	1	TRMU [mitochondrial matrix] (R-HSA-6787370)	0.499	3
UniProt:O15455 TLR3	6	TLR3 [endosome membrane] (R-HSA-2000341) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 E746* [endosome membrane] (R-HSA-5602730)	0.463	2

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