Reactome | MBL2 [extracellular region]

MBL2 [extracellular region]

Stable Identifier

R-HSA-166674

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MBL monomer

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds MASP2 (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11226 MBL2

Gene Names

MBL2, COLEC1, MBL

Chain

signal peptide:1-20, chain:21-248

Reference Genes

BioGPS Gene:4153 MBL2

COSMIC (genes):MBL2 MBL2

CTD Gene:4153 MBL2

dbSNP Gene:4153 MBL2

ENSEMBL:ENSG00000165471 MBL2

ENSEMBL:ENSG00000165471.7 MBL2

HGNC:6922 MBL2

KEGG Gene (Homo sapiens):4153 MBL2

Monarch:4153 MBL2

NCBI Gene:4153 MBL2

OMIM:154545 MBL2

UCSC:P11226 MBL2

Reference Transcript

Other Identifiers

11734301_at

11734302_at

11764210_at

16714409

207256_PM_at

207256_at

3289788

3289789

3289790

3289791

3289792

3289793

3289794

3289796

3289797

3289798

3289799

3289802

32945_i_at

32946_r_at

4153

66189_at

7933665

A_24_P206679

GE476728

GE59726

GO:0001867

GO:0002376

GO:0002682

GO:0002752

GO:0005102

GO:0005515

GO:0005537

GO:0005576

GO:0005581

GO:0005615

GO:0005768

GO:0005771

GO:0005783

GO:0005791

GO:0005886

GO:0006508

GO:0006953

GO:0006954

GO:0006958

GO:0006979

GO:0008228

GO:0009897

GO:0009986

GO:0016192

GO:0023052

GO:0030246

GO:0031410

GO:0042742

GO:0042802

GO:0043129

GO:0043226

GO:0045087

GO:0048306

GO:0048525

GO:0050766

GO:0050830

GO:0051873

GO:0098542

GO:0140374

GO:1903028

GO:1905370

HMNXSV003045983

ILMN_1762464

PH_hs_0000312

TC10001301.hg

X15422_at

X15954_rna1_s_at

g4557738_3p_at

Participates

as a component of

MBL2 trimer [extracellular region] (Homo sapiens)

Inferred To

Homologues of MBL2 [extracellular region] (Danio rerio)

Homologues of MBL2 [extracellular region] (Xenopus tropicalis)

Mbl2 [extracellular region] (Mus musculus)

Mbl2 [extracellular region] (Rattus norvegicus)

mbl2 [extracellular region] (Xenopus tropicalis)

MBL2 [extracellular region] (Danio rerio)

MBL2 [extracellular region] (Sus scrofa)

colec10 [extracellular region] (Danio rerio)

LOC100496055 [extracellular region] (Xenopus tropicalis)

MBL [extracellular region] (Bos taurus)

MBL [extracellular region] (Gallus gallus)

igsf9b [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_000233.1, XP_011538118.1, XP_006717924.1

OpenTargets

ENSG00000165471

GeneCards

P11226

HPA

ENSG00000165471-MBL2

Ensembl

ENSP00000502789, ENST00000674931, ENSP00000502615, ENST00000675947, ENST00000373968, ENSG00000165471, ENSP00000363079

PRO

P11226

Pharos - Targets

P11226

Orphanet

23731

PDB

1HUP

HMDB Protein

HMDBP02647

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
mannan [ChEBI:28808]	1	alpha-mannan [plasma membrane] (R-ALL-5621136)	0.945	15
UniProt:P17927 CR1	3	CR1 [ficolin-1-rich granule membrane] (R-HSA-6801286) CR1 [secretory granule membrane] (R-HSA-6801315) CR1 [plasma membrane] (R-HSA-977369)	0.623	8
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.558	5
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.558	2
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.544	6
UniProt:O15455 TLR3	6	TLR3 E746* [endosome membrane] (R-HSA-5602730) TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endosome membrane] (R-HSA-2000341)	0.463	2