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MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
Stable Identifier
R-HSA-166719
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Creation of C4 and C2 activators (Homo sapiens)
Lectin pathway of complement activation (Homo sapiens)
Activation of MASPs (Homo sapiens)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15199963
The lectin-complement pathway--its role in innate immunity and evolution
Endo, Y
,
Fujita, T
,
Matsushita, M
Immunol Rev
2004
Participants
components
Bacterial mannose surface pattern [plasma membrane]
x 4
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
(Homo sapiens)
Participates
as an output of
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
as a member of
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Inferred To
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
(Bos taurus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
(Gallus gallus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
(Mus musculus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
(Rattus norvegicus)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane]
(Sus scrofa)
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