Activation of MASPs

Stable Identifier
R-HSA-166726
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of MASPs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MBL or ficolins binding to carbohydrates on the target surface results in conformational changes in the lectin:MASPs complex. It in turn promotes a cleavage of proenzyme form of MASP between the CCP2 and the serine protease domains, which results in the generation of the active form. The active form of MASP-2 is able to cleave C4 and C2 to generate the C3 convertase (Vorup-Jensen T et al. 2000; Chen CB and Wallis R 2004). The active form of MASP-1 was shown to facilitate the complement activation by either direct cleavage of complex-bound MASP-2 or cleavage of C2 bound to C4 (Matsushita M et al. 2000; Heja D et al. 2012).
Literature References
PubMed ID Title Journal Year
10925294 Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2

Petersen, SV, Davis, SJ, Sim, RB, Schwaeble, W, Jensenius, JC, Thiel, S, Poulsen, K, Reid, KB, Hansen, AG, Vorup-Jensen, T

J Immunol 2000
Participants
Input
Output
Participates
as an event of
Orthologous Events
Activation of MASPs (Bos taurus)
Activation of MASPs (Canis familiaris)
Activation of MASPs (Gallus gallus)
Activation of MASPs (Mus musculus)
Activation of MASPs (Rattus norvegicus)
Activation of MASPs (Sus scrofa)
Activation of MASPs (Xenopus tropicalis)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2005-09-15)
Cite Us!