Formation of Classical C3 convertase (C4b:C2a complex)

Stable Identifier
R-HSA-166795
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

C4b and C2a form a complex termed the classical pathway C3 convertase (Muller-Eberhard et al. 1967). C2a that fails to bind C4b is rapidly inactivated.

Literature References
PubMed ID Title Journal Year
6019133 Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement

Muller-Eberhard, HJ, Polley, MJ, Calcott, MA

J Exp Med 1967
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created