Signalling to RAS

Stable Identifier
R-HSA-167044
Type
Pathway
Species
Homo sapiens
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Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells.

Literature References
PubMed ID Title Journal Year
11520933 Nerve growth factor signaling, neuroprotection, and neural repair

Sofroniew, MV, Howe, CL, Mobley, WC

Annu Rev Neurosci 2001
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