NGF processing

Stable Identifier
R-HSA-167060
Type
Pathway
Species
Homo sapiens
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All neurotrophins (NTs) are generated as pre-pro-neurotrophin precursors. The signal peptide is cleaved off as NT is associated with the endoplasmic reticulum (ER). The resulting pro-NT can form a homodimer spontaneously which then transits to the Golgi apparatus and then onto the trans-Golgi network (TGN). Resident protein convertases (PCs) can cleave off the pro-sequence and mature NT is is targeted to constitutively released vesicles. The pro-NT form can also be released to the extracellular region.

Literature References
PubMed ID Title Journal Year
12787574 Neurotrophin secretion: current facts and future prospects

Lessmann, V, Gottmann, K, Malcangio, M

Prog Neurobiol 2003
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Orthologous Events
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