Reactome | NTF3 [extracellular region]

NTF3 [extracellular region]

Stable Identifier

R-HSA-167062

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

NT3, Neurotrophin-3

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
        
        NTF3 homodimer [extracellular region] (Homo sapiens)
        
        NTF3 [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
        
        NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
        
        NTF3 homodimer [extracellular region] (Homo sapiens)
        
        NTF3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20783 NTF3

Gene Names

NTF3

Chain

signal peptide:1-18, propeptide:19-138, chain:139-257

Reference Genes

BioGPS Gene:4908 NTF3

COSMIC (genes):NTF3 NTF3

CTD Gene:4908 NTF3

dbSNP Gene:4908 NTF3

ENSEMBL:ENSG00000185652 NTF3

ENSEMBL_homo_sapiens_GENE:ENSG00000185652.12 NTF3

HGNC:8023 NTF3

KEGG Gene (Homo sapiens):4908 NTF3

Monarch:4908 NTF3

NCBI Gene:4908 NTF3

OMIM:162660 NTF3

UCSC:P20783 NTF3

Reference Transcript

Other Identifiers

11758373_s_at

206706_PM_at

206706_at

3402151

3402164

3402165

3402166

3402167

35041_at

4908

7953284

A_14_P138442

A_23_P360797

GE522376

GO:0002092

GO:0005102

GO:0005163

GO:0005165

GO:0005515

GO:0005576

GO:0005615

GO:0007165

GO:0007169

GO:0007267

GO:0007399

GO:0007422

GO:0007613

GO:0008021

GO:0008083

GO:0008284

GO:0012501

GO:0016192

GO:0021675

GO:0023052

GO:0030154

GO:0030335

GO:0030424

GO:0030425

GO:0031410

GO:0032148

GO:0033138

GO:0036211

GO:0038180

GO:0042056

GO:0042981

GO:0043226

GO:0043406

GO:0043524

GO:0045664

GO:0048018

GO:0048812

GO:0048856

GO:0048870

GO:0050731

GO:0050732

GO:0050804

GO:0050877

GO:0050918

GO:0050930

GO:0090630

GO:0098772

HMNXSV003005652

ILMN_1809364

M37763_at

PH_hs_0005512

g9845503_3p_at

Participates

as a component of

NTF3 homodimer [extracellular region] (Homo sapiens)

Inferred To

ntf3 [extracellular region] (Xenopus tropicalis)

Ntf3 [extracellular region] (Mus musculus)

Ntf3 [extracellular region] (Rattus norvegicus)

NTF3 [extracellular region] (Bos taurus)

NTF3 [extracellular region] (Canis familiaris)

NTF3 [extracellular region] (Gallus gallus)

NTF3 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001096124.1, NP_002518.1, XP_011519265.1

OpenTargets

ENSG00000185652

GeneCards

P20783

HPA

ENSG00000185652-NTF3

Ensembl

ENSP00000328738, ENSG00000185652, ENSP00000397297, ENST00000331010, ENST00000423158

PRO

P20783

Pharos - Targets

P20783

PDB

1NT3, 3BUK, 1B8K, 1BND

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07174 Ngfr	8	Ngfr [nucleoplasm] (R-RNO-197473) Ngfr [plasma membrane] (R-RNO-194509) Ngfr [cytosol] (R-RNO-194458) Ngfr [endosome] (R-RNO-209541) Ngfr [plasma membrane] (R-RNO-194476) Ngfr [extracellular region] (R-RNO-194470) Tumor necrosis factor receptor superfamily member 16 [plasma membrane] (R-RNO-193863) Ngfr [plasma membrane] (R-RNO-193664)	0.655	4
UniProt:P23560 BDNF	2	BDNF(1-247) [endoplasmic reticulum lumen] (R-HSA-187041) BDNF [extracellular region] (R-HSA-167028)	0.59	3

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