Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Stable Identifier
R-HSA-167072
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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This HIV-1 event was inferred from the corresponding human RNA Pol II transcription event. FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and, therefore, is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE).

Literature References
PubMed ID Title Journal Year
12370301 FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation.

Mandal, SS, Cho, H, Kim, S, Cabane, K, Reinberg, D

Mol Cell Biol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of CTDP1 [nucleoplasm]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Created