Phosphorylation (Ser5) of RNA pol II CTD

Stable Identifier
R-HSA-167098
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
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Phosphorylation (Ser5) of RNA pol II CTD
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Phosphorylation of serine 5 residue at the CTD of pol II largest subunit is an important step signaling the end of initiation and escape into processive elongation processes. Cdk7 protein subunit of TFIIH phosphorylates RNA Pol II CTD serine 5 residues on its heptad repeats (Buratowski 2009).

Literature References
PubMed ID Title Journal Year
19941815 Progression through the RNA polymerase II CTD cycle

Buratowski, S

Mol. Cell 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Pol II transcription complex containing extruded transcript to +30 [nucleoplasm]
Physical Entity
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Inferred From
Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2005-10-11)
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