Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition

Stable Identifier
R-HSA-167117
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Formation of phosphodiester bonds nine and ten creates RNA products, which do not dissociate from the RNA pol II initiation complex. The transcription complex has enter the productive elongation phase. TFIIH and ATP-hydrolysis are required for efficient promoter escape. The open region (“transcription bubble”) expands concomitant with the site of RNA-extension. The region upstream from the transcription start site (-9 to -3) collapses to the double-stranded state. TFIIH remains associated to the RNA pol II initiation complex.
Literature References
PubMed ID Title Journal Year
7601352 Recycling of the general transcription factors during RNA polymerase II transcription.

Zawel, L, Kumar, KP, Reinberg, D

Genes Dev 1995
9405375 Three transitions in the RNA polymerase II transcription complex during initiation.

Fiedler, U, Timmers, HT, Holstege, FC

EMBO J 1998
Participants
Participates
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]

Inferred From
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Created
Cite Us!