SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

Stable Identifier
R-HSA-167153
Type
Reaction
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
Summation

The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript (Gonatopoulos-Pournatzis et al.2011).

Literature References
PubMed ID Title Journal Year
24354960 Cap-binding complex (CBC) Biochem. J. 2014
Participants
Participant Of
Inferred From
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection