Reactome | BRK1 [cytosol]

BRK1 [cytosol]

Stable Identifier

R-HSA-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSPC300, Protein BRICK1, BRK1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUW1 BRK1

Gene Names

BRK1, C3orf10, HSPC300, MDS027

Chain

initiator methionine:1, chain:2-75

Reference Genes

BioGPS Gene:55845 BRK1

COSMIC (genes):BRK1 BRK1

CTD Gene:55845 BRK1

dbSNP Gene:55845 BRK1

ENSEMBL:ENSG00000254999 BRK1

HGNC:23057 BRK1

KEGG:hsa:55845 BRK1

Monarch:55845 BRK1

NCBI Gene:55845 BRK1

OMIM:611183 BRK1

UCSC:Q8WUW1 BRK1

Reference Transcript

RefSeq:NM_018462.4 BRK1

Other Identifiers

11715979_x_at

16937563

224575_PM_at

224575_at

2610318

2610319

2610320

2610321

2610322

2610323

2610325

55845

56418_at

8077770

A_23_P420361

A_24_P157342

GE688143

GO:0001701

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0007015

GO:0008064

GO:0010592

GO:0016601

GO:0030027

GO:0030036

GO:0031209

GO:0031267

GO:0031334

GO:0042802

GO:0044877

GO:0048144

GO:0048146

GO:0048856

GO:0048870

GO:0070062

GO:2000601

HMNXSV003057320

Hs.273369.2.S1_3p_at

ILMN_1764500

PH_hs_0019746

PH_hs_0035943

PH_hs_0037792

TC03000053.hg

Participates

as a candidate of

as a component of

Inferred To

Ghost homologue of BRK1 [cytosol] (Canis familiaris)

Ghost homologue of BRK1 [cytosol] (Gallus gallus)

Ghost homologue of BRK1 [cytosol] (Xenopus tropicalis)

Brk1 [cytosol] (Mus musculus)

Brk1 [cytosol] (Rattus norvegicus)

HSPC300 [cytosol] (Drosophila melanogaster)

BRK1 [cytosol] (Bos taurus)

BRK1 [cytosol] (Caenorhabditis elegans)

BRK1 [cytosol] (Sus scrofa)

brk1 [cytosol] (Danio rerio)

brk1 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_060932.2

ENSEMBL

ENST00000530758, ENSG00000254999, ENSP00000432472

OpenTargets

ENSG00000254999

GeneCards

BRK1

HPA

ENSG00000254999-BRK1

PRO

Q8WUW1

Pharos - Targets

Q8WUW1

PDB

4N78, 3P8C, 7USE, 7USD, 7USC

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.666	4
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:O15534 PER1	4	PER1 [cytosol] (R-HSA-400373) p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) K48polyUb-K,p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.556	3
UniProt:P41231 P2RY2	1	P2RY2 [plasma membrane] (R-HSA-417923)	0.556	3
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.527	3
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.527	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	3
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.527	2
UniProt:Q9NUP1 BLOC1S4	1	BLOC1S4 [cytosol] (R-HSA-429817)	0.527	3
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.527	3

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