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ABI2 [cytosol]
Stable Identifier
R-HSA-1671647
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Abl interactor 2, ABI2_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYB9 ABI2
Gene Names
ABI2, ARGBPIA
Chain
chain:1-513
Reference Genes
BioGPS Gene:10152 ABI2
COSMIC (genes):ABI2 ABI2
CTD Gene:10152 ABI2
dbSNP Gene:10152 ABI2
ENSEMBL:ENSG00000138443 ABI2
HGNC:24011 ABI2
KEGG Gene (Homo sapiens):10152 ABI2
Monarch:10152 ABI2
NCBI Gene:10152 ABI2
OMIM:606442 ABI2
UCSC:Q9NYB9 ABI2
Reference Transcript
RefSeq:NM_001282925.1 ABI2
RefSeq:XM_006712185.1 ABI2
RefSeq:NM_001282927.1 ABI2
RefSeq:NM_005759.5 ABI2
RefSeq:NM_001282926.1 ABI2
Other Identifiers
10152
1040_s_at
11727019_at
11727020_at
11727021_a_at
11746841_a_at
11746842_x_at
11746843_a_at
11751403_a_at
11751404_x_at
11760619_x_at
134_at
135_g_at
16889779
207268_x_at
209856_x_at
211793_s_at
225098_at
225112_at
231075_x_at
2523690
2523691
2523692
2523703
2523704
2523705
2523710
2523716
2523718
2523720
2523725
2523728
2523729
2523730
2523731
2523733
2523734
2523735
2523736
2523737
2523738
2523739
2523740
2523741
2523742
2523747
2523748
2523749
2523751
36448_at
44746_at
52796_at
65721_at
8047659
A_14_P101630
A_23_P79692
A_24_P933418
GE81557
GE85898
GO:0000902
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005912
GO:0006464
GO:0007010
GO:0007165
GO:0007399
GO:0008092
GO:0008093
GO:0008150
GO:0008154
GO:0016032
GO:0016477
GO:0016601
GO:0017124
GO:0018108
GO:0019899
GO:0019900
GO:0022607
GO:0030027
GO:0030054
GO:0030154
GO:0030175
GO:0030674
GO:0031209
GO:0031625
GO:0032433
GO:0032991
GO:0034330
GO:0040011
GO:0042802
GO:0042995
GO:0043197
GO:0043226
GO:0044403
GO:0048365
GO:0048856
GO:0048870
GO:0061001
GO:0065003
GO:0070064
GO:0070309
GO:2000601
Hs.285728.0.A1_3p_at
Hs.285728.0.A2_3p_at
Hs.42656.1.A1_3p_at
ILMN_1720988
ILMN_1724497
ILMN_1775944
PH_hs_0024439
TC02001198.hg
U23435_s_at
X95632_s_at
X95677_at
g7839523_3p_a_at
Participant Of
hasCandidate
ABI [cytosol]
Other forms of this molecule
p-4S-ABI2 [cytosol]
Inferred To
abi-1 [cytosol] (Caenorhabditis elegans)
ABI2 [cytosol] (Canis familiaris)
ABI2 [cytosol] (Gallus gallus)
ABI2 [cytosol] (Sus scrofa)
ABI2 [cytosol] (Xenopus tropicalis)
abi2a [cytosol] (Danio rerio)
abiA [cytosol] (Dictyostelium discoideum)
Abi2 [cytosol] (Mus musculus)
Cross References
RefSeq
NP_001269855.1
,
NP_001269854.1
,
NP_001269856.1
,
XP_006712248.1
,
NP_005750.4
OpenTargets
ENSG00000138443
GeneCards
Q9NYB9
HPA
ENSG00000138443-ABI2
Ensembl
ENST00000261017
,
ENSG00000138443
,
ENSP00000261017
PRO
Q9NYB9
PDB
4N78
,
2ED0
,
3P8C
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IY31 IFT20
3
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.742
6
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.742
6
UniProt:O14964 HGS
2
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
HGS [cytosol]
(R-HSA-182954)
0.666
5
UniProt:Q9UL45 BLOC1S6
1
BLOC1S6 [cytosol]
(R-HSA-429816)
0.666
5
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.666
5
UniProt:O00560 SDCBP
3
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
0.666
5
UniProt:P54646 PRKAA2
4
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.666
5
UniProt:P50552 VASP
2
VASP [cytosol]
(R-HSA-446323)
VASP [cytosol]
(R-HSA-426404)
0.666
5
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
SUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.666
6
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.666
5
UniProt:P00519 ABL1
5
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
0.524
2
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