HIV Transcription Elongation

Stable Identifier
R-HSA-167169
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
ReviewStatus
5/5
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In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation is incomplete with non-processive polymerases disengaging from the proviral DNA template prematurely (reviewed in Karn 1999). The mechanism of Tat-mediated elongation is described below.
Literature References
PubMed ID Title Journal Year
10550206 Tackling Tat

Karn, J

J Mol Biol 1999
15049426 Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages

Herrmann, CH, Rice, AP

Curr HIV Res 2003
Participants
Participates
Event Information
Inferred From
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Created
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