Abortive elongation of HIV-1 transcript in the absence of Tat

Stable Identifier
R-HSA-167242
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

This event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated with the HIV-1 template are non-processive. RNA Pol II is arrested after promoter clearance by the negative transcriptional elongation factors DSIF and NELF as occurs during early elongation of endogenous templates (Wada et al, 1998; Yamaguchi et al. 1999). This arrest cannot be overcome by P-TEFb mediated phosphorylation in the absence of Tat however, and elongation aborts resulting in the accumulation of short transcripts (Kao et al., 1987).

Literature References
PubMed ID Title Journal Year
9450929 DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.

Wada, T, Takagi, T, Yamaguchi, Y, Ferdous, A, Imai, T, Hirose, S, Sugimoto, S, Yano, K, Hartzog, GA, Winston, F, Buratowski, S, Handa, H

Genes Dev 1998
2825027 Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

Kao, SY, Calman, AF, Luciw, PA, Peterlin, BM

Nature 1987
10199401 NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

Yamaguchi, Y, Takagi, T, Wada, T, Yano, K, Furuya, A, Sugimoto, S, Hasegawa, J, Handa, H

Cell 1999
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Created