G-protein alpha subunit is inactivated

Stable Identifier
R-HSA-167415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Slow intrisinc GTPase activity results in an inactivation of the alpha-i subunit by hydrolyzing GTP to GDP.

Literature References
PubMed ID Title Journal Year
8073283 Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

Coleman, DE, Berghuis, AM, Lee, E, Linder, ME, Gilman, AG, Sprang, SR

Science 1994
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Raw, AS, Lee, E, Sprang, SR, Gilman, AG

Proc Natl Acad Sci U S A 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of G-protein alpha (i/o/z/t) subunit [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created