Abortive termination of HIV-1 early transcription elongation by DSIF:NELF

Stable Identifier
R-HSA-167478
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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In the early elongation phase, shorter transcripts typically of ~30 nt in length are generated due to random termination of elongating nascent transcripts. This abortive cessation of elongation has been observed mainly in the presence of DSIF-NELF bound to Pol II complex. (Reviewed in Conaway et al.,2000; Shilatifard et al., 2003 ).

Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Shilatifard, A, Conaway, RC, Conaway, JW

Annu Rev Biochem 2003
10916156 Control of elongation by RNA polymerase II.

Conaway, JW, Shilatifard, A, Dvir, A, Conaway, RC

Trends Biochem Sci 2000
Participants
Participant Of
Inferred From
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Created