Reactome | SH2B1-2 [cytosol]

SH2B1-2 [cytosol]

Stable Identifier

R-HSA-1675482

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2B1 beta, SH2B1_HUMAN, SH2B1 isoform 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NRF2-2 SH2B1

Gene Names

SH2B1, KIAA1299, SH2B

Other Identifiers

0002970725

11735737_a_at

11735738_x_at

11749834_a_at

11749835_x_at

11749855_a_at

16817438

209322_s_at

25970

3655013

3655015

3655016

3655017

3655018

3655019

3655020

3655021

3655022

3655023

3655024

3655025

3655026

3655027

3655028

3655029

3655030

3655032

3655033

3655034

3655035

3655036

3655037

3655038

3655039

3655040

3655041

3655042

3655045

3655046

3655047

40149_at

5W3R

76175

7994445

A0A024QZ92

A0A024QZC2

A0A024QZD2

A_14_P134753

A_24_P185029

AAF73912

AAF73913

AAF73914

AAH10704

AB037720

AC133550

AF227967

AF227968

AF227969

AK027488

AK290332

AL049924

AL713760

B4DLN5

BAA92537

BAB55148

BAF83021

BC010704

CAB43208

CAD28530

CCDS32424

CCDS53996

CCDS53997

CH471267

EAW51999

EAW52000

EAW52001

EAW52003

EAW52004

EAW52005

ENSG00000178188

ENSP00000321221

ENSP00000337163

ENSP00000352232

ENSP00000378903

ENSP00000481709

ENST00000322610

ENST00000322610.12

ENST00000337120

ENST00000337120.9

ENST00000359285

ENST00000359285.9

ENST00000395532

ENST00000395532.8

ENST00000618521

ENST00000618521.4

EntrezGene:25970

F5GXU7

g8163910_3p_s_at

GE53890

GO:0003674

GO:0005068

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0007165

GO:0007169

GO:0007596

GO:0009967

GO:0016020

GO:0019899

GO:0022607

GO:0030032

GO:0030674

GO:0035556

GO:0035591

GO:0043226

GO:0045840

GO:2000278

H3BMY3

H3BPZ4

H3BTK4

H3BVF6

HGNC:30417

HPA076175

ILMN_1698521

ILMN_2061185

IPR000980

IPR001849

IPR011993

IPR015012

IPR030521

IPR030523

IPR035057

IPR036290

IPR036860

MIM:608937

NM_001145795

NM_001145796

NM_001145797

NM_001145812

NM_001308293

NM_015503

NP_001139267

NP_001139268

NP_001139269

NP_001139284

NP_001295222

NP_056318

PF00017

PF00169

PF08916

PH_hs_0001456

PR00401

SH2B1

SH2B1-201

SH2B1-202

SH2B1-203

SH2B1-204

SH2B1-216

SM00233

SM00252

TC16000309.hg

UPI00001AF36C

UPI0000246E38

UPI00004894E6

XM_017023114

XM_017023115

XM_017023116

XM_017023117

XM_017023118

XM_017023119

XM_017023120

XM_024450225

XM_024450226

XP_016878603

XP_016878604

XP_016878605

XP_016878606

XP_016878607

XP_016878608

XP_016878609

XP_024305993

XP_024305994

XR_001751890

Participant Of

hasComponent

input

Inferred To

Ghost homologue of SH2B1-2 [cytosol] (Danio rerio)

Ghost homologue of SH2B1-2 [cytosol] (Xenopus tropicalis)

SH2B1-2 [cytosol] (Bos taurus)

SH2B1-2 [cytosol] (Canis familiaris)

SH2B1-2 [cytosol] (Mus musculus)

SH2B1-2 [cytosol] (Rattus norvegicus)

SH2B1-2 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016878603.1, XP_016878605.1, XP_016878604.1, NP_001139268.1, NP_001295222.1, NP_001139269.1, NP_001295223.1, NP_056318.2, NP_001139267.1, NP_001139284.1

OpenTargets

ENSG00000178188

GeneCards

Q9NRF2

PRO

Q9NRF2

Orphanet

20852

PDB

5W3R

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.592	2
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799)	0.527	2
UniProt:P52631 Stat3	9	phospho-p-STAT3 [cytosol] (R-RNO-8982823) phospho-p-STAT3 [nucleoplasm] (R-RNO-8983188) phospho-p-Y705-STAT3 [nucleoplasm] (R-RNO-9027589) phospho-p-Y705-STAT3 [cytosol] (R-RNO-8983130) phospho-p-Y705,S727-STAT3 [cytosol] (R-RNO-539048) Phospho-STAT3 [cytosol] (R-RNO-198649) phospho-p-Y705-STAT3 [cytosol] (R-RNO-914048) Signal transducer and activator of transcription 3 [cytosol] (R-RNO-198734) phospho-p-Y705-STAT3 [nucleoplasm] (R-RNO-1112554)	0.524	2