Reactome | SH2B1-2 [cytosol]

SH2B1-2 [cytosol]

Stable Identifier

R-HSA-1675482

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2B1 beta, SH2B1_HUMAN, SH2B1 isoform 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NRF2-2 SH2B1

Gene Names

SH2B1, KIAA1299, SH2B

Other Identifiers

0002970725

0101410148

11735737_a_at

11735738_x_at

11749834_a_at

11749835_x_at

11749855_a_at

16817438

209322_s_at

25970

3655013

3655015

3655016

3655017

3655018

3655019

3655020

3655021

3655022

3655023

3655024

3655025

3655026

3655027

3655028

3655029

3655030

3655032

3655033

3655034

3655035

3655036

3655037

3655038

3655039

3655040

3655041

3655042

3655045

3655046

3655047

3655057

3655059

40149_at

7994445

A_14_P134753

A_24_P185029

GE53890

GO:0000278

GO:0003674

GO:0005068

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006259

GO:0006950

GO:0007049

GO:0007165

GO:0007169

GO:0007596

GO:0008150

GO:0009058

GO:0009967

GO:0016020

GO:0019899

GO:0022607

GO:0030032

GO:0030674

GO:0034641

GO:0035556

GO:0035591

GO:0043226

GO:0045840

GO:0060391

GO:0140014

GO:2000278

ILMN_1698521

ILMN_2061185

PH_hs_0001456

TC16000309.hg

g8163910_3p_s_at

Participant Of

hasComponent

input

Inferred To

sh2b1 [cytosol] (Danio rerio)

Ghost homologue of SH2B1-2 [cytosol] (Xenopus tropicalis)

SH2B1-2 [cytosol] (Bos taurus)

SH2B1-2 [cytosol] (Gallus gallus)

Sh2b1 [cytosol] (Mus musculus)

Sh2b1 [cytosol] (Rattus norvegicus)

SH2B1 [cytosol] (Canis familiaris)

SH2B1 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016878603.1, XP_016878605.1, NP_001295222.1, NP_001139267.1, NP_001139268.1, XP_016878604.1, NP_001295223.1, NP_056318.2, NP_001139269.1, NP_001139284.1

OpenTargets

ENSG00000178188

HPA

ENSG00000178188-SH2B1

GeneCards

Q9NRF2

Ensembl

ENSP00000337163, ENSP00000321221, ENSP00000378903, ENST00000359285, ENST00000322610, ENST00000618521, ENSP00000352232, ENSP00000481709, ENST00000395532, ENST00000337120, ENSG00000178188

PRO

Q9NRF2

Orphanet

20852

PDB

5W3R

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.773	4
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799)	0.527	2
UniProt:P52631 Stat3	9	phospho-Stat3 [cytosol] (R-RNO-8982823) phospho-Stat3 [nucleoplasm] (R-RNO-8983188) phospho-Stat3 [cytosol] (R-RNO-539048) Phospho-STAT3 [cytosol] (R-RNO-198649) phospho-Stat3 [nucleoplasm] (R-RNO-9027589) phospho-Stat3 [cytosol] (R-RNO-8983130) phospho-Stat3 [cytosol] (R-RNO-914048) Signal transducer and activator of transcription 3 [cytosol] (R-RNO-198734) phospho-Stat3 [nucleoplasm] (R-RNO-1112554)	0.524	2

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