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About
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SH2B1-2 [cytosol]
Stable Identifier
R-HSA-1675482
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH2B1 beta, SH2B1_HUMAN, SH2B1 isoform 2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
SH2B binds JAK2 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1:p-IRS1,2 [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1 [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1 [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] (Homo sapiens)
SH2B1-2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRF2-2 SH2B1
Gene Names
SH2B1, KIAA1299, SH2B
Other Identifiers
0002970725
0101410148
11735737_a_at
11735738_x_at
11749834_a_at
11749835_x_at
11749855_a_at
16817438
209322_s_at
25970
3655013
3655015
3655016
3655017
3655018
3655019
3655020
3655021
3655022
3655023
3655024
3655025
3655026
3655027
3655028
3655029
3655030
3655032
3655033
3655034
3655035
3655036
3655037
3655038
3655039
3655040
3655041
3655042
3655045
3655046
3655047
3655057
3655059
40149_at
5W3R
76175
7994445
A0A024QZ92
A0A024QZC2
A0A024QZD2
A_14_P134753
A_24_P185029
AAF73912
AAF73913
AAF73914
AAH10704
AB037720
AC133550
AF227967
AF227968
AF227969
AK027488
AK290332
AL049924
AL713760
B4DLN5
BAA92537
BAB55148
BAF83021
BC010704
CAB43208
CAD28530
CCDS32424
CCDS53996
CCDS53997
CH471267
EAW51999
EAW52000
EAW52001
EAW52003
EAW52004
EAW52005
ENSG00000178188
ENSP00000321221
ENSP00000337163
ENSP00000352232
ENSP00000378903
ENSP00000481709
ENST00000322610
ENST00000322610.12
ENST00000337120
ENST00000337120.9
ENST00000359285
ENST00000359285.9
ENST00000395532
ENST00000395532.8
ENST00000618521
ENST00000618521.4
EntrezGene:25970
EntrezGene:SH2B1
F5GXU7
g8163910_3p_s_at
GE53890
GO:0000278
GO:0003674
GO:0005068
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006259
GO:0006950
GO:0007049
GO:0007165
GO:0007169
GO:0007596
GO:0008150
GO:0009058
GO:0009967
GO:0016020
GO:0019899
GO:0022607
GO:0030032
GO:0030674
GO:0034641
GO:0035556
GO:0035591
GO:0043226
GO:0045840
GO:0140014
GO:2000278
H3BMY3
H3BPZ4
H3BTK4
H3BVF6
HGNC:30417
HPA076175
ILMN_1698521
ILMN_2061185
IPR000980
IPR001849
IPR011993
IPR015012
IPR030521
IPR030523
IPR035057
IPR036290
IPR036860
MIM:608937
NM_001145795
NM_001145796
NM_001145797
NM_001145812
NM_001308293
NM_015503
NP_001139267
NP_001139268
NP_001139269
NP_001139284
NP_001295222
NP_056318
PF00017
PF00169
PF08916
PH_hs_0001456
PR00401
SH2B
SH2B1
SH2B1-201
SH2B1-202
SH2B1-203
SH2B1-204
SH2B1-216
SM00233
SM00252
TC16000309.hg
UPI00001AF36C
UPI0000246E38
UPI00004894E6
XM_017023115
XP_016878603
XP_016878604
XP_016878605
Participant Of
hasComponent
LEP:p-LEPR:p-JAK2:SH2B1 [plasma membrane]
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane]
LEP:p-LEPR:p-JAK2:SH2B1:p-IRS1,2 [plasma membrane]
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]
input
Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
SH2B binds JAK2
Inferred To
Ghost homologue of SH2B1-2 [cytosol] (Xenopus tropicalis)
SH2B1-2 [cytosol] (Bos taurus)
SH2B1-2 [cytosol] (Canis familiaris)
SH2B1-2 [cytosol] (Danio rerio)
SH2B1-2 [cytosol] (Mus musculus)
SH2B1-2 [cytosol] (Rattus norvegicus)
SH2B1-2 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_001295223.1
,
NP_001139284.1
,
XP_016878605.1
,
NP_001139267.1
,
NP_056318.2
,
NP_001295222.1
,
NP_001139269.1
,
NP_001139268.1
,
XP_016878604.1
,
XP_016878603.1
OpenTargets
ENSG00000178188
GeneCards
Q9NRF2
PRO
Q9NRF2
Orphanet
20852
PDB
5W3R
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.592
2
UniProt:O60674 JAK2
8
p-Y1007,Y1008-JAK2 [cytosol]
(R-HSA-9005327)
p-JAK2 [cytosol]
(R-HSA-210621)
p-Y813-JAK2 [cytosol]
(R-HSA-997248)
JAK2 V617F [nucleoplasm]
(R-HSA-5211269)
JAK2 [endosome lumen]
(R-HSA-2002372)
p-12Y-JAK2 [cytosol]
(R-HSA-2586516)
JAK2 [cytosol]
(R-HSA-210620)
p-Y1007-JAK2 [cytosol]
(R-HSA-873799)
0.527
2
UniProt:P52631 Stat3
9
phospho-p-STAT3 [cytosol]
(R-RNO-8982823)
phospho-p-STAT3 [nucleoplasm]
(R-RNO-8983188)
phospho-p-Y705-STAT3 [nucleoplasm]
(R-RNO-9027589)
Phospho-STAT3 [cytosol]
(R-RNO-198649)
phospho-p-Y705-STAT3 [cytosol]
(R-RNO-8983130)
phospho-p-Y705,S727-STAT3 [cytosol]
(R-RNO-539048)
phospho-p-Y705-STAT3 [cytosol]
(R-RNO-914048)
Signal transducer and activator of transcription 3 [cytosol]
(R-RNO-198734)
phospho-p-Y705-STAT3 [nucleoplasm]
(R-RNO-1112554)
0.524
2
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