PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

Stable Identifier
R-HSA-1675776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [cytosol]
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Activity
Orthologous Events
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