PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane

Stable Identifier
R-HSA-1675780
Type
Reaction [transition]
Species
Homo sapiens
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At the plasma membrane, phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) (Balla et al. 2002, Minogue et al. 2001) and beta (PI4K2B) (Balla et al. 2002, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P).

Literature References
PubMed ID Title Journal Year
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Sun, HQ, Yamamoto, M, Wlodarski, P, Kunii, K, Martínez, M, Barylko, B, Albanesi, JP, Yin, HL

J Biol Chem 2002
11279162 Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family

Minogue, S, Anderson, JS, Waugh, MG, dos Santos, M, Corless, S, Cramer, R, Hsuan, JJ

J Biol Chem 2001
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, A, Tuymetova, G, Barshishat, M, Geiszt, M, Balla, T

J Biol Chem 2002
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Catalyst Activity
Title
1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]
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