Reactome | ATP6V1H [cytosol]

ATP6V1H [cytosol]

Stable Identifier

R-HSA-167578

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

v-ATPase

Locations in the PathwayBrowser for interactor UniProt:Q9BZL4 PP12C

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of phagosomal maturation (Homo sapiens)
        
        Blockage of phagosome acidification (Homo sapiens)
        
        PtpA binds ATP6V1H (Homo sapiens)
        
        ATP6V1H [cytosol] (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef Mediated CD4 Down-regulation (Homo sapiens)
        
        Degradation of CD4 (Homo sapiens)
        
        ATP6V1H [cytosol] (Homo sapiens)
        
        Nef Mediated CD8 Down-regulation (Homo sapiens)
        
        Degradation of CD8 (Homo sapiens)
        
        ATP6V1H [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UI12 ATP6V1H

Gene Names

ATP6V1H, CGI-11

Chain

chain:1-483

Reference Genes

BioGPS Gene:51606 ATP6V1H

COSMIC (genes):ATP6V1H ATP6V1H

CTD Gene:51606 ATP6V1H

dbSNP Gene:51606 ATP6V1H

ENSEMBL:ENSG00000047249 ATP6V1H

HGNC:18303 ATP6V1H

KEGG:hsa:51606 ATP6V1H

Monarch:51606 ATP6V1H

NCBI Gene:51606 ATP6V1H

OMIM:608861 ATP6V1H

UCSC:Q9UI12 ATP6V1H

Reference Transcript

Other Identifiers

11715609_a_at

17077194

221504_PM_s_at

221504_s_at

3135453

3135454

3135455

3135456

3135460

3135461

3135463

3135464

3135465

3135471

3135472

3135473

3135478

3135479

3135480

3135484

3135485

3135486

3135488

3135490

3135491

3135492

3135494

3135495

3135496

3135497

3135498

3135499

3135500

3135501

3135502

3135503

33741_at

33742_f_at

51606

8150797

89225_at

A_23_P157478

A_24_P363679

GE58620

GE84640

GO:0000139

GO:0000221

GO:0003824

GO:0005215

GO:0005515

GO:0005765

GO:0005829

GO:0005886

GO:0006897

GO:0007035

GO:0007042

GO:0010008

GO:0016020

GO:0016192

GO:0016241

GO:0016787

GO:0016887

GO:0030234

GO:0030665

GO:0031410

GO:0033176

GO:0043226

GO:0046961

GO:0048388

GO:0051452

GO:0055085

GO:0061795

GO:0070062

GO:0097401

GO:0098772

GO:0098850

GO:0140657

GO:1902495

GO:1902600

HMNXSV003000384

ILMN_1689473

ILMN_2403730

PH_hs_0001719

TC08001215.hg

g6563195_3p_s_at

Participates

as a component of

as an input of

PtpA binds ATP6V1H (Homo sapiens)

as an output of

Other forms of this molecule

ATP6V1H [plasma membrane]

Inferred To

vatH [cytosol] (Dictyostelium discoideum)

ATP6V1H [cytosol] (Bos taurus)

ATP6V1H [cytosol] (Canis familiaris)

ATP6V1H [cytosol] (Gallus gallus)

ATP6V1H [cytosol] (Plasmodium falciparum)

ATP6V1H [cytosol] (Sus scrofa)

Atp6v1h [cytosol] (Mus musculus)

Atp6v1h [cytosol] (Rattus norvegicus)

vma13 [cytosol] (Schizosaccharomyces pombe)

VMA13 [cytosol] (Saccharomyces cerevisiae)

atp6v1h [cytosol] (Danio rerio)

atp6v1h [cytosol] (Xenopus tropicalis)

VhaSFD [cytosol] (Drosophila melanogaster)

vha-15 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006716518.1, NP_057025.2, NP_998784.1, NP_998785.1

Guide to Pharmacology - Targets

822

OpenTargets

ENSG00000047249

ENSEMBL

ENSP00000347359, ENST00000355221, ENST00000396774, ENST00000359530, ENSP00000352522, ENSP00000379995

HPA

ENSG00000047249-ATP6V1H

PRO

Q9UI12

Pharos - Targets

Q9UI12

GlyGen

Q9UI12

PDB

7FDC, 7FDA, 7U4T, 7FDB, 7UNF, 6WM3, 6WM2, 6WM4

HMDB Protein

HMDBP04017

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q96Q35-2 FLACC1			0.556	3
UniProt:Q9BZL4 PP12C			0.556	3
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.556	3
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.556	3
UniProt:Q96IK1-2 Q96IK12			0.556	3
UniProt:O15079 SNPH			0.556	3
UniProt:Q16864 ATP6V1F	1	ATP6V1F [cytosol] (R-HSA-912603)	0.527	3
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.527	3
UniProt:Q9Y5K8 ATP6V1D	3	ATP6V1D [plasma membrane] (R-HSA-6800455) ATP6V1D [specific granule membrane] (R-HSA-6799710) ATP6V1D [cytosol] (R-HSA-912597)	0.527	3