Reactome | PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

Stable Identifier

R-HSA-1675813

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Wong et al. 1997, Gehrmann et al. 1999) or phosphatidylinositol 4-kinase type 2-beta (PI4K2B) (Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References

PubMed ID	Title	Journal	Year
12324459	Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP Wei, YJ, Sun, HQ, Yamamoto, M, Wlodarski, P, Kunii, K, Martínez, M, Barylko, B, Albanesi, JP, Yin, HL	J Biol Chem	2002
9148941	Subcellular locations of phosphatidylinositol 4-kinase isoforms Wong, K, Meyers, ddR, Cantley, LC	J Biol Chem	1997
10101268	Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230 Gehrmann, T, Gülkan, H, Suer, S, Herberg, FW, Balla, A, Vereb, G, Mayr, GW, Heilmeyer LM, Jr	Biochim Biophys Acta	1999