PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

Stable Identifier
R-HSA-1675824
Type
Reaction [transition]
Species
Homo sapiens
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At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) (Choudhury et al. 2009, Suchy et al. 1995, Zhang et al. 1995) and 72 kDa inositol polyphosphate 5-phosphatase (INPP5E) (Bilas et al. 2009) dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). INPP5E is located in the Golgi membrane, mediated by its N-terminal proline-rich domain (Kong et al. 2000).

Literature References
PubMed ID Title Journal Year
10764818 The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase

Kisseleva, MV, Wilson, MP, Majerus, PW

J Biol Chem 2000
19211563 Differential clathrin binding and subcellular localization of OCRL1 splice isoforms

Choudhury, R, Noakes, CJ, McKenzie, E, Kox, C, Lowe, M

J Biol Chem 2009
10806194 Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network

Kong, AM, Speed, CJ, O'Malley, CJ, Layton, MJ, Meehan, T, Loveland, KL, Cheema, S, Ooms, LM, Mitchell, CA

J Biol Chem 2000
8634694 Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus

Suchy, SF, Olivos-Glander, IM, Nussabaum, RL

Hum Mol Genet 1995
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Zhang, X, Jefferson, AB, Auethavekiat, V, Majerus, PW

Proc Natl Acad Sci U S A 1995
19668216 Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

Bielas, SL, Silhavy, JL, Brancati, F, Kisseleva, MV, Al-Gazali, L, Sztriha, L, Bayoumi, RA, Zaki, MS, Abdel-Aleem, A, Rosti, RO, Kayserili, H, Swistun, D, Scott, LC, Bertini, E, Boltshauser, E, Fazzi, E, Travaglini, L, Field, SJ, Gayral, S, Jacoby, M, Schurmans, S, Dallapiccola, B, Majerus, PW, Valente, EM, Gleeson, JG

Nat Genet 2009
Participants
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Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of OCRL/INPP5E [cytosol]
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