PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane

Stable Identifier
R-HSA-1675834
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, early endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mice, phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) translocates from the plasma membrane to the early endosome membrane (Watt et al. 2004). A similar event has also been detected in cells from Chlorocebus sabaeus (Green Monkey) (Ivetac et al. 2005). In humans this event is inferred from the other two occurrences.
Literature References
PubMed ID Title Journal Year
15716355 The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

Luff, S, Majerus, PW, Kisseleva, MV, Rowe, T, Zhang, XM, Tiganis, T, Munday, AD, Ivetac, I, Mitchell, CA, Whisstock, JC

Mol Biol Cell 2005
14604433 Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

Leslie, NR, Kimber, WA, Lucocq, JM, Downes, CP, Watt, SA, Fleming, IN

Biochem J 2004
Participants
Input
Output
Participates
as an event of
Inferred From
PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Mus musculus)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
Cite Us!