Reactome | AP2M1 [plasma membrane]

AP2M1 [plasma membrane]

Stable Identifier

R-HSA-167585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

AP-2 clathrin coat assembly protein, Clathrin -coated Pit Adapter Protein

Locations in the PathwayBrowser for interactor UniProt:Q9P0T4 ZN581

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HIV Infection (Homo sapiens)
    - Host Interactions of HIV factors (Homo sapiens)
      - The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef mediated downregulation of CD28 cell surface expression (Homo sapiens)
        
        Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)
        
        AP2M1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96CW1 AP2M1

Gene Names

AP2M1, CLAPM1, KIAA0109

Chain

chain:1-435

Reference Genes

BioGPS Gene:1173 AP2M1

COSMIC (genes):AP2M1 AP2M1

CTD Gene:1173 AP2M1

dbSNP Gene:1173 AP2M1

ENSEMBL:ENSG00000161203 AP2M1

HGNC:564 AP2M1

KEGG Gene (Homo sapiens):1173 AP2M1

Monarch:1173 AP2M1

NCBI Gene:1173 AP2M1

OMIM:601024 AP2M1

UCSC:Q96CW1 AP2M1

Reference Transcript

Other Identifiers

0000870341

11724231_s_at

1173

11746645_x_at

11747195_x_at

11749846_x_at

16948738

200613_at

2655477

2655479

2655480

2655481

2655484

2655486

2655490

2655491

2655493

2655494

2655495

2655497

2655498

2655501

2655504

2655505

2655506

2655507

2655508

2655509

2655510

39795_at

8084345

A_33_P3378800

D63475_at

GE57272

GO:0002376

GO:0003674

GO:0005048

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006810

GO:0006886

GO:0006897

GO:0006900

GO:0007165

GO:0007267

GO:0008150

GO:0008289

GO:0009056

GO:0015031

GO:0016020

GO:0016192

GO:0019886

GO:0022607

GO:0030122

GO:0030131

GO:0030666

GO:0030669

GO:0031410

GO:0031623

GO:0032802

GO:0032991

GO:0034383

GO:0034622

GO:0035615

GO:0036020

GO:0043226

GO:0043231

GO:0044325

GO:0044403

GO:0045334

GO:0048013

GO:0048856

GO:0050690

GO:0050750

GO:0060071

GO:0061024

GO:0065003

GO:0070062

GO:0072583

GO:0097494

GO:1903077

ILMN_1699598

ILMN_2402798

PH_hs_0025297

TC03000994.hg

g4757993_3p_x_at

Participant Of

hasComponent

input

Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex

Other forms of this molecule

AP2M1 [cytosol]

AP2M1 [clathrin-coated endocytic vesicle membrane]

AP2M1 [endolysosome membrane]

AP2M1 [lysosomal membrane]

p-T156 AP2M1 [cytosol]

Inferred To

ap2m1a [plasma membrane] (Danio rerio)

Ap2m1 [plasma membrane] (Mus musculus)

Ap2m1 [plasma membrane] (Rattus norvegicus)

APM4 [plasma membrane] (Saccharomyces cerevisiae)

AP2M1 [plasma membrane] (Canis familiaris)

AP2M1 [plasma membrane] (Gallus gallus)

AP2M1 [plasma membrane] (Sus scrofa)

apm4 [plasma membrane] (Schizosaccharomyces pombe)

dpy-23 [plasma membrane] (Caenorhabditis elegans)

ap2m1 [plasma membrane] (Xenopus tropicalis)

apm2 [plasma membrane] (Dictyostelium discoideum)

AP-2mu [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001298127.1, NP_004059.2, NP_001020376.1

Target Pathogen

5b354852be737e166372e774

OpenTargets

ENSG00000161203

GeneCards

Q96CW1

HPA

ENSG00000161203-AP2M1

Ensembl

ENST00000292807, ENSP00000292807, ENST00000439647, ENSP00000409081, ENSP00000371894, ENST00000382456, ENSG00000161203

PRO

Q96CW1

Orphanet

28614

PDB

1H6E, 6BNT

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92609 TBCD5			0.737	4
UniProt:P63010 AP2B1	4	AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.678	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.667	5
UniProt:Q9UHP6 RSP14			0.666	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.643	5
UniProt:Q2M2I8 AAK1	1	AAK1 [cytosol] (R-HSA-8854795)	0.643	3
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.593	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:Q99633 PRP18			0.556	3
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.556	3
UniProt:Q9BSU3 NAA11			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.556	5
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	3
UniProt:Q8N9N8 EIF1A			0.556	3
IntAct:EBI-16429620 CCSB ORF ID			0.556	3
UniProt:Q96EY4 TMA16			0.556	3
UniProt:Q8N8X9 MB213			0.556	5
UniProt:P62807 H2BC4	9	Ub-HIST1H2BC [nucleoplasm] (R-HSA-6782552) HIST1H2BC [extracellular region] (R-HSA-977564) AcK-HIST1H2BC [nucleoplasm] (R-HSA-4549246) AcK16-HIST1H2BC [nucleoplasm] (R-HSA-4568634) AcK6-HIST1H2BC [nucleoplasm] (R-HSA-4568623) AcK13-HIST1H2BC [nucleoplasm] (R-HSA-4568620) AcK21-HIST1H2BC [nucleoplasm] (R-HSA-4568626) Ub-121-HIST1H2BC [nucleoplasm] (R-HSA-3364029) HIST1H2BC [nucleoplasm] (R-HSA-181906)	0.556	5
UniProt:Q86YD7 F90A1			0.556	5
UniProt:P55081 MFAP1	1	MFAP1 [extracellular region] (R-HSA-2396419)	0.556	3
UniProt:Q1ED39 KNOP1			0.556	3
UniProt:Q99880 H2BC13	9	Ub-HIST1H2BL [nucleoplasm] (R-HSA-6782543) HIST1H2BL [extracellular region] (R-HSA-977579) AcK-HIST1H2BL [nucleoplasm] (R-HSA-4549254) AcK13-HIST1H2BL [nucleoplasm] (R-HSA-4568650) AcK16-HIST1H2BL [nucleoplasm] (R-HSA-4568697) AcK6-HIST1H2BL [nucleoplasm] (R-HSA-4568719) AcK21-HIST1H2BL [nucleoplasm] (R-HSA-4568674) Ub-121-HIST1H2BL [nucleoplasm] (R-HSA-3364013) HIST1H2BL [nucleoplasm] (R-HSA-181920)	0.556	3
UniProt:Q00013 EM55			0.556	5
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074) MMTAG2 [secretory granule lumen] (R-HSA-6801073)	0.556	3
UniProt:Q03393 PTS	2	p-S19-PTS [cytosol] (R-HSA-1475426) PTS [cytosol] (R-HSA-1475061)	0.556	3
UniProt:Q68CQ4 DIEXF	1	DIEXF [nucleoplasm] (R-HSA-6790689)	0.556	5
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	5
UniProt:Q16778 H2BC21	9	Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539) HIST2H2BE [extracellular region] (R-HSA-977571) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) HIST2H2BE [nucleoplasm] (R-HSA-181908)	0.556	3
UniProt:P0DPH9 CX05B			0.556	3
UniProt:P51116 FXR2			0.553	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.553	2
UniProt:P27958-PRO_0000037566			0.543	4
UniProt:O94973 AP2A2	6	AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.527	2
UniProt:P0DTD1-PRO_0000449628 REP			0.527	2
UniProt:P42566 EPS15	2	p-Y850 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.527	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q01968 OCRL	4	OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [Golgi membrane] (R-HSA-434339) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.508	3
UniProt:A9UF07 A9UF07			0.462	2

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