PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

Stable Identifier
R-HSA-1675988
Type
Reaction [transition]
Species
Homo sapiens
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At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka Synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007, Johenning et al. 2004) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 4-phosphate (PI4P) phosphatidylinositol (PI). The SAC1 domains of SYNJ1 and SYNJ2 demonstrate 4-phosphatase activity.

Literature References
PubMed ID Title Journal Year
15080793 InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1

Johenning, FW, Wenk, MR, Uhlén, P, Degray, B, Lee, E, De Camilli, P, Ehrlich, BE

Biochem J 2004
18093523 The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

Mani, M, Lee, SY, Lucast, L, Cremona, O, Di Paolo, G, De Camilli, P, Ryan, TA

Neuron 2007
11084340 Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

Malecz, N, McCabe, PC, Spaargaren, C, Qiu, R, Chuang, Y, Symons, M

Curr Biol 2000
10224048 SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

Guo, S, Stolz, LE, Lemrow, SM, York, JD

J Biol Chem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phosphate 4-phosphatase activity of SYNJs,OCRL [cytosol]
Physical Entity
Activity
Orthologous Events
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Created