Reactome | PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

Stable Identifier

R-HSA-1676020

Type

Reaction [transition]

Species

Homo sapiens

Compartment

late endosome membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
17556371	Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex Sbrissa, D, Ijuin, T, Gruenberg, J, Fu, Z, Shisheva, A, Takenawa, T, Ikonomov, OC	J Biol Chem	2007
18950639	ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality Sbrissa, D, Shisheva, A, Ikonomov, OC, Fenner, H	J Mol Biol	2008