Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome

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R-HSA-1676041
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Reaction
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Homo sapiens
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The presence of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) in the early endosome membrane stimulates the vesicle maturation into the late endosome (Cabezas et al. 2006, Ikonomov et al. 2006, Ikonomov et al. 2001).

Literature References
PubMed ID Title Journal Year
16510848 Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion

Ikonomov, OC, Sbrissa, D, Shisheva, A

Am J Physiol Cell Physiol 2006
11285266 Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve

Ikonomov, OC, Sbrissa, D, Shisheva, A

J Biol Chem 2001
16448788 Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1

Cabezas, A, Pattni, K, Stenmark, H

Gene 2006
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