PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane

Stable Identifier
R-HSA-1676048
Type
Reaction [transition]
Species
Homo sapiens
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At the plasma membrane, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits form complexes with regulatory subunits. These complexes phosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) (Stephens et al. 1997). The PI(4,5)P2 3-kinase complexes involved are: PI(4,5)P2 3-kinase catalytic subunit alpha isoform (PIK3CA) bound to PI 3-kinase regulatory subunit alpha/beta/gamma (PIK3R1/2/3); beta (PIK3CB) bound to PIK3R1/2/3; delta (PIK3CD) bound to PIK3R1/2/3; and gamma (PIK3CG) bound to PI 3-kinase regulatory subunit 5 (PIK3R5) or 6 (PIK3R6).

The following lists the above proteins with their corresponding literature references: PIK3CA:PIK3R1, PIK3CA:PIK3R2, PIK3CA:PIK3R3 (Dey et al. 1998, Vanhaesebroeck et al. 1997, Meier et al. 2004); PIK3CB:PIK3R1, PIK3CB:PIK3R2, PIK3CB:PIK3R3 (Meier et al. 2004); PIK3CD:PIK3R1, PIK3CD:PIK3R2, PIK3CD:PIK3R3 (Vanhaesebroeck et al. 1997, Meier et al. 2004); and PIK3CG:PIK3R5, PIK3CG:PIK3R6 (Voigt et al. 2006, Suire et al. 2005, Stoyanov et al. 1995).

Literature References
PubMed ID Title Journal Year
9113989 P110delta, a novel phosphoinositide 3-kinase in leukocytes

Vanhaesebroeck, B, Welham, MJ, Kotani, K, Stein, R, Warne, PH, Zvelebil, MJ, Higashi, K, Volinia, S, Downward, J, Waterfield, MD

Proc Natl Acad Sci U S A 1997
9094719 The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

Stephens, LR, Eguinoa, A, Erdjument-Bromage, H, Lui, M, Cooke, F, Coadwell, J, Smrcka, AS, Thelen, M, Cadwallader, K, Tempst, P, Hawkins, PT

Cell 1997
16476736 Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B

Voigt, P, Dorner, MB, Schaefer, M

J Biol Chem 2006
15135396 Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms

Meier, TI, Cook, JA, Thomas, JE, Radding, JA, Horn, C, Lingaraj, T, Smith, MC

Protein Expr Purif 2004
15797027 p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

Suire, S, Coadwell, J, Ferguson, GJ, Davidson, K, Hawkins, P, Stephens, L

Curr Biol 2005
9524259 Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor

Dey, BR, Furlanetto, RW, Nissley, SP

Gene 1998
7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Stoyanov, B, Volinia, S, Hanck, T, Rubio, I, Loubtchenkov, M, Malek, D, Stoyanova, S, Vanhaesebroeck, B, Dhand, R, Nurnberg, B

Science 1995
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Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PIK3C(1) [cytosol]
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Orthologous Events
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