PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004), MTMR2 (Cao et al. 2008), MTMR4 (Lorenzo et al. 2006), and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).
Literature References
PubMed ID Title Journal Year
12890864 Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9

Majerus, PW, Mochizuki, Y

Proc Natl Acad Sci U S A 2003
16787938 Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions

Lorenzo, O, Clague, MJ, Urbé, S

J Cell Sci 2006
14722070 Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction

Ijuin, T, Shisheva, A, Takenawa, T, Tsujita, K, Laporte, J, Yamamoto, A, Itoh, T

J Biol Chem 2004
18524850 Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking

Bedrick, EJ, Wandinger-Ness, A, Cao, C, Laporte, J, Backer, JM

Mol Biol Cell 2008
14660569 Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

Payrastre, B, Pendaries, C, Pirola, L, Laporte, J, Tronchère, H, Mandel, JL, Chaussade, C, Liaubet, L

J Biol Chem 2004
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM

Traffic 2007
Catalyst Activity

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4,MTMR7 [cytosol]

Orthologous Events
Cross References
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