PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

Stable Identifier
R-HSA-1676082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002).

This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al. 2004, 2007).

Literature References
PubMed ID Title Journal Year
17245604 Phospholipase D signaling: orchestration by PIP2 and small GTPases

Oude Weernink, PA, López de Jesús, M, Schmidt, M

Naunyn Schmiedebergs Arch Pharmacol 2007
15464023 Regulation and cellular roles of phosphoinositide 5-kinases

Oude Weernink, PA, Schmidt, M, Jakobs, KH

Eur J Pharmacol 2004
9211928 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

Zhang, X, Loijens, JC, Boronenkov, IV, Parker, GJ, Norris, FA, Chen, J, Thum, O, Prestwich, GD, Majerus, PW, Anderson, RA

J Biol Chem 1997
12422219 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

Di Paolo, G, Pellegrini, L, Letinic, K, Cestra, G, Zoncu, R, Voronov, S, Chang, S, Guo, J, Wenk, MR, De Camilli, P

Nature 2002
16979564 A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis

Halstead, JR, van Rheenen, J, Snel, MH, Meeuws, S, Mohammed, S, D'Santos, CS, Heck, AJ, Jalink, K, Divecha, N

Curr Biol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1A-C [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created