PI4P is dephosphorylated to PI by SACM1L at the ER membrane

Stable Identifier
R-HSA-1676124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, transmembrane protein phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

Literature References
PubMed ID Title Journal Year
14527956 The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex

Rohde, HM, Cheong, FY, Konrad, G, Paiha, K, Mayinger, P, Boehmelt, G

J Biol Chem 2003
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Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]
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