PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane

Stable Identifier
R-HSA-1676133
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
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At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) efficiently dephosphorylates phosphatidylinositol 4-phosphate (PI4P), and to a lesser extent phosphatidylinositol 3-phosphate (PI3P), to phosphatidylinositol (PI). No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

Literature References
PubMed ID Title Journal Year
14527956 The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex

Rohde, HM, Cheong, FY, Konrad, G, Paiha, K, Mayinger, P, Boehmelt, G

J Biol Chem 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [Golgi membrane]
Physical Entity
SACM1L [Golgi membrane]
Activity
phosphatidylinositol phosphate 4-phosphatase activity (0034596)
Orthologous Events
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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