PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane

Stable Identifier
R-HSA-1676134
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A) and beta (PIP5K1B) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Tolias et al. 1998).

Literature References
PubMed ID Title Journal Year
9660759 Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

Tolias, KF, Rameh, LE, Ishihara, H, Shibasaki, Y, Chen, J, Prestwich, GD, Cantley, LC, Carpenter, CL

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-3-phosphate 5-kinase activity of PIP5K1A/B [cytosol]
Physical Entity
Activity
Orthologous Events
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