Reactome | PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane

PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane

Stable Identifier

R-HSA-1676141

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane

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At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Kim et al. 2002), MTMR2 (Cao et al. 2008, Kim et al. 2002), and MTMR4 (Lorenzo et al. 2006, Zhao et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
16787938	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions Lorenzo, O, Urbé, S, Clague, MJ	J Cell Sci	2006
11302699	FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate Zhao, R, Qi, Y, Chen, J, Zhao, ZJ	Exp Cell Res	2001
18524850	Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking Cao, C, Backer, JM, Laporte, J, Bedrick, EJ, Wandinger-Ness, A	Mol Biol Cell	2008
17651088	Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP	Traffic	2007
11733541	Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease Kim, SA, Taylor, GS, Torgersen, KM, Dixon, JE	J Biol Chem	2002