Reactome | PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

Stable Identifier

R-HSA-1676162

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

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At the early endosome membrane, type I (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) (Norris et al. 1997) colocalise with early and recycling endosomes through their C2 domains which bind to the phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) present in these membranes. It is here that phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is dephosphorylated by INPP4A/B to phosphatidylinositol 3-phosphate (PI3P).

Literature References

PubMed ID	Title	Journal	Year
7608176	The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase Auethavekiat, V, Majerus, PW, Norris, FA	J Biol Chem	1995
15716355	The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane Luff, S, Majerus, PW, Kisseleva, MV, Rowe, T, Zhang, XM, Tiganis, T, Munday, AD, Ivetac, I, Mitchell, CA, Whisstock, JC	Mol Biol Cell	2005
9295334	The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family Atkins, RC, Majerus, PW, Norris, FA	J Biol Chem	1997